Cancer Biology Training Grant

描述（由申请人提供）：这个博士前和博士后培训计划强调板凳到床边的研究，包括癌症研究的最先进的领域。沿着在癌症研究和健全的科学理论的基础培训，学生将在基本的药物发现使用高通量化学和遗传筛选，以确定细胞网络，信号转导途径，DNA损伤和修复反应，和纳米靶向治疗药物输送使用细胞和动物分子成像的培训。癌症问题在21世纪世纪仍然是一个国家的优先事项，因此，提供了一个实质性的长期职业机会，为博士前和博士后学生的培训。我们的培训计划的目标是（a）培养能够进行独立的癌症研究的高素质的科学家;（B）培养在当今和未来的学术或工业领域取得成功所需的智力，技术和沟通技能;（c）提供对人类癌症的基本，公共卫生和临床问题的理解。该培训补助金能够将基础科学学院现有的优秀基础与西蒙斯综合癌症中心新开发的癌症生物学和治疗计划联系起来，使其与标准化的普通研究生和研究生教育计划区分开来。我们有30承诺教师培训代表16个不同的部门和中心在UT西南。我们已经召集了一个专门的领导小组，他们将组成培训计划的指导委员会，沿着行政支持以及癌症中心主任的智力和财政支持。我们为博士前和博士后学员制定了一项综合计划，详细介绍了癌症教育和培训的所有关键步骤，包括生物医学伦理和负责任的科学行为。我们有一个计划的具体计划，招聘一个地理范围广泛的博士前和博士后申请人以及代表性不足的少数民族学员。我们已经扩大并实施了我们的癌症教学和期刊导向课程，包括基础和翻译以及每月的癌症中心实习生会议。该癌症生物学培训计划将满足所有北德克萨斯州的需求，该地区目前没有癌症研究培训。

DESCRIPTION (provided by applicant): This predoctoral and postdoctoral training program emphasizes bench to bedside research encompassing state-of-the-art areas of cancer research. Along with training in the fundamentals of cancer research and sound scientific theory, students will be trained in fundamental drug discovery using high throughput chemical and genetic screens to define cellular networks, signal transduction pathways, DNA damage and repair responses, and nanomedicine-targeted therapeutic drug delivery using cell and animal molecular imaging. The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for the training of predoctoral and postdoctoral students. The goals of our training program are to (a) train top-quality scientists capable of conducting independent cancer research; (b) foster the intellectual, technical, and communication skills required to succeed in the academic or industrial arenas of today and in the future; and (c) provide an understanding of the basic, public health, and clinical problems of human cancer. The ability of this training grant to bridge an existing outstanding foundation of Faculty in Basic Science with newly developed Cancer Biology and Therapy Programs in the Simmons Comprehensive Cancer Center, distinguishes it from a standardized general graduate and post- graduate educational program. We have 30 committed Faculty Trainers representing 16 different Departments and Centers at UT Southwestern. We have assembled a dedicated group of leaders that will constitute the Steering Committee of the Training Program, along with Administrative Support and both intellectual and financial support from the Director of the Cancer Center. We have an integrated plan for the proposed Cancer Training Program for both predoctoral and postdoctoral trainees that details all key steps in cancer education and training, including biomedical ethics and the responsible conduct of science. We have a program specific plan for recruiting a geographically broad range of predoctoral and postdoctoral applicants as well as underrepresented minorities trainees. We have expanded and implemented our cancer didactic and journal oriented courses, both basic and translational as well as a monthly cancer center trainee meeting. This Cancer Biology Training Program will serve the needs of all North Texas, an area where no current cancer research training is present.