Cancer Biology Training Grant

描述(由申请者提供)：这个博士后和博士后培训计划强调从工作台到床边的研究，包括最先进的癌症研究领域。除了癌症研究的基础知识和健全的科学理论方面的培训外，学生和博士后研究员还将接受许多癌症研究基本领域的培训，包括使用高通量化学和遗传筛选来定义细胞网络、信号转导途径、DNA损伤和修复反应的药物发现，以及使用细胞和动物分子成像的纳米药物靶向治疗性药物输送。21世纪的癌症问题仍然是国家的优先事项，因此，为培养博士后和博士后学生提供了一个实质性的长期职业机会。我们培训计划的目标是：(A)培养能够进行独立癌症研究的高素质科学家；(B)培养在当今和未来的学术或工业领域取得成功所需的智力、技术和沟通技能；以及(C)提供对人类癌症的基本、公共卫生和临床问题的了解。这笔培训补助金能够将现有优秀的基础科学系基础与我们在哈罗德·西蒙斯国家癌症研究所指定的癌症中心的癌症生物学和治疗项目联系起来，这一能力使其有别于标准化的普通研究生和研究生教育项目。我们有43名忠诚的教员培训师，代表德克萨斯大学西南分校24个不同的部门和中心。我们已经组建了一个由指导委员会成员组成的专门小组，以及来自癌症中心主任的行政支持以及智力和财政支持。我们为拟议的针对博士后和博士后学员的癌症培训计划制定了一个综合计划，详细说明了癌症教育和培训中的所有关键步骤，包括生物医学伦理、负责任的科学行为、生物统计学、生物信息学和数据共享。我们有一个具体的项目计划，以招聘和保留广泛的地理范围的博士前和博士后申请者，以及代表不足的多样性学员。我们已经扩展和实施了我们的癌症教学和面向期刊的课程，包括基础课程和翻译课程。在过去的4年里，我们国内合格的博士后和博士后申请者人数几乎翻了一番，我们的教职培训师人数增加了大约50%。

DESCRIPTION (provided by applicant): This predoctoral and postdoctoral training program emphasizes bench to bedside research encompassing state-of-the-art areas of cancer research. Along with training in the fundamentals of cancer research and sound scientific theory, students and postdoctoral fellows will be trained in many fundamental areas of cancer research including, drug discovery using high throughput chemical and genetic screens to define cellular networks, signal transduction pathways, DNA damage and repair responses, and nanomedicine-targeted therapeutic drug delivery using cell and animal molecular imaging. The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for the training of predoctoral and postdoctoral students. The goals of our training program are to (a) train top-quality scientists capable of conducting independent cancer research; (b) foster the intellectual, technical, and communication skills required to succeed in the academic or industrial arenas of today and in the future; and (c) provide an understanding of the basic, public health, and clinical problems of human cancer. The ability of this training grant to bridge an existing outstanding foundation of Faculty in Basic Science with our Cancer Biology and Therapy Programs in the Harold Simmons NCI Designated Cancer Center, distinguishes it from a standardized general graduate and post-graduate educational program. We have 43 committed Faculty Trainers representing 24 different Departments and Centers at UT Southwestern. We have assembled a dedicated group of Steering Committee members, along with Administrative Support and both intellectual and financial support from the Director of the Cancer Center. We have an integrated plan for the proposed Cancer Training Program for both predoctoral and postdoctoral trainees that details all key steps in cancer education and training, including biomedical ethics, the responsible conduct of science, biostatistics, bioinformatics, and data sharing. We have a program specific plan for recruiting and retaining a geographically broad range of predoctoral and postdoctoral applicants as well as underrepresented diversity trainees. We have expanded and implemented our cancer didactic and journal oriented courses, both basic and translational. Our domestic eligible predoctoral and postdoctoral applicant pool has almost doubled during the last 4 years and our Faculty Trainer pool has increased by approximately 50%.