Research Training in Infections and Immunity

描述（由申请人提供）：此NRSA竞争应用程序将允许贝勒医学院（Baylor College of Medicine）的学员继续成功开展传染病临床研究职业。在这个时候，我们是唯一的NRSA现有的在得克萨斯州医学中心内，以追求临床研究培训非艾滋病感染。一流的培训机会存在于许多领域的培训。参与的项目具有良好的联邦资助记录和培训经验，包括：1）先天免疫和医院感染，2）基于新药、细胞和益生菌的治疗剂，3）病毒和细菌性胃肠炎，4）病毒和细菌致病和肿瘤发生，5）急性呼吸道病原体和肺炎，6）疫苗开发和评估，7）结核病，（8）感染。2007年，对参与该NRSA方案的特定中心和方案的赠款支助总额为1 950万美元。该方案的结构包括三个组成部分，代表受训人员可以从事的培训轨道：1）以实验室为基础的临床研究，2）临床研究试验和3）临床流行病学。所有追求实验室为基础的轨道的学员将被要求参加临床科学家培训计划（CSTP; K30）在斯坦福大学;医生学员将获得他们的MS在临床研究。那些追求临床流行病学轨道被要求进入公共卫生（UTHSPH）的得克萨斯大学休斯顿学院，并获得他们的MPH。那些追求临床试验轨道的学员将进入CSTP或UTHSPH，并分别获得他们的MS或MPH。成人传染病培训计划在传染病临床研究表明，它可以吸引高素质的博士后学员，其中一半以上是妇女和近四分之一的代表性不足的少数民族，并为他们提供必要的技能，开始成功的职业生涯。在本周期，该方案有5名受训人员毕业，他们都被任命为主要医学院或大学的助理教授。这些人总共发表了60篇经过同行评审的原创手稿，并获得了几项著名的赠款和职业发展奖，总额为160万美元。这一成功的记录，沿着申请人数量的翻倍和10名新教师导师/共同导师的参与，作为支持每年更新3名博士后学员的证据，比本周期的2名学员有所增加。

DESCRIPTION (provided by applicant): This NRSA competing application will allow trainees at Baylor College of Medicine (BCM) to continue to successfully launch clinical research careers in infectious diseases. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center to pursue clinical research training in non-AIDS infections. Superb training opportunities exist at BCM in a number of areas. Participating projects with a strong record of federal funding and training experience include: 1) Innate Immunity and Nosocomial Infections, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Pathogenesis and Oncogenesis, 5), Acute Respiratory Pathogens and Pneumonia, 6) Vaccine Development and Evaluation, 7) Tuberculosis, and 8) Prostheses Infections. Total grant support in 2007 for the specific centers and programs participating in this NRSA Program is $19.5M. The structure of the Program contains three components, representing training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical research trials and 3) clinical epidemiology. All trainees pursuing the laboratory-based track will be required to participate in the Clinical Scientist Training Program (CSTP; K30) at BCM; physician trainees will obtain their MS in Clinical Investigation. Those pursuing the clinical epidemiology track are required to enter the University of Texas-Houston School of Public Health (UTHSPH) and obtain their MPH. Those trainees pursuing the clinical trials track will enter either the CSTP or UTHSPH and obtain their MS or MPH, respectively. The Adult Infectious Diseases Training Program at BCM has shown it can attract highly qualified postdoctoral trainees, over half of them women and close to a quarter under-represented minorities, and provide them with the skills necessary to begin successful careers in infectious diseases clinical research. In the current cycle, this Program has graduated 5 trainees, all of whom were appointed to the Assistant Professor level in a major medical college or university. Altogether, these individuals have published 60 original peer-reviewed manuscripts and have been awarded several prestigious grants and career development awards, totaling $1.6M. This record of success, along with a doubling in the pool of applicants and the participation of 10 new Faculty Mentors/Co-Mentors, is offered as evidence in support of renewal with 3 postdoctoral trainees per year, an increase from 2 trainees in the current cycle.