Research Training in Infection and Immunity

描述(由申请人提供)：这是一份NRSA竞争续签申请，为期12-17年，旨在培养传染病和免疫学研究前沿的研究人员。受训者将处于博士后水平，博士和博士混杂在一起，每人支持两年，每年总共要求3笔津贴。来实现这一目标。目前，我们是BCM或德克萨斯医学中心内唯一支持非艾滋病感染和全球健康临床研究培训的NRSA。BCM在许多领域都有极好的培训机会。由23名导师(8名医学博士、4名医学博士和11名博士)指导并具有丰富的联邦资助和培训经验的参与项目包括：1)天然免疫的细胞和结构生物学，2)基于药物、细胞和益生菌的新疗法，3)病毒和细菌性胃肠炎，4)病毒和细菌的致癌，5)疫苗的开发和评估，6)病毒和细胞纳米机器的高分辨率结构，7)病原体的功能基因组学，8)与设备相关的感染。2014财年，对参与该NRSA计划的项目的赠款支持总额约为3300万美元。感染和免疫研究培训计划的结构包括学员可以进行的三个培训途径：1)基于实验室的临床研究，2)临床试验和流行病学研究，3)全球卫生研究。项目总监David J.Tweardy医学博士负责维护项目的最终权威，并管理日常运营。他得到了执行委员会的另外两名成员的协助，他们是副项目主任Mary Estes博士和国家热带医学院院长Peter Hotez医学博士。受训人员的遴选由遴选委员会进行，该委员会包括执行委员会和其他三名项目教员。MD研究员的培训计划包括研究轮换，以帮助选择导师。医学博士和博士生都有单独的研究委员会，必须准备一份书面研究提案，并向研究委员会进行辩护，并进行年度审查，其中包括学术和职业评估。医学博士和博士生都被要求参加每月进行中的研究系列研讨会，每周一次的期刊俱乐部，以及每年一次的科学社会活动。所有受训人员必须出席这些会议。参加这次NRSA的BCM和其他部门的成人和儿科传染病培训计划表明，他们可以吸引高素质、有培训资助的合格博士后学员候选人，包括每年近两名代表不足的少数族裔候选人。到目前为止，已有12名学员完成了该奖项资助的培训。作为一个群体，他们通过博士后培训共发表了118篇同行评议的手稿(每名研究生9.8篇手稿；59%是由本科生第一次撰写的)。此外，这些毕业生还从NIH和其他有竞争力的渠道获得了总计490万美元的外部资金。除了一名毕业生外，所有毕业生都在继续从事学术或行业传染病职业。

DESCRIPTION (provided by applicant): This is the resubmission of a NRSA competing renewal application for Years 12-17 of a training program designed to produce investigators at the cutting edge of research in infectious diseases and immunity. Trainees will be at the postdoctoral level and a mixture of MDs and PhDs each supported for 2 years for a total request of 3 stipends/yr. to accomplish this goal. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center that supports clinical research training in non-AIDS infections and global health. Superb training opportunities exist at BCM in a number of areas. Participating projects directed by 23 mentors (8 MDs, 4 MD/PhDs and 11 PhDs) with strong records of federal funding and training experience include: 1) Cellular and Structural Biology of Innate Immunity, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Oncogenesis, 5) Vaccine Development and Evaluation, 6) High- resolution Structures of Viruses and Cellular Nanomachines, 7) Functional Genomics of Pathogens, and 8) Device-related Infections. Total grant support in FY2014 for the projects participating in this NRSA Program is approximately $33M. The structure of the Program for Research Training in Infections and Immunity contains three training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical trials and epidemiology research and 3) global health research. The Program Director, David J. Tweardy MD, maintains ultimate authority for the program and manages day-to-day operations. He is assisted by two other member of the Executive Committee, Associate Program Director, Mary Estes PhD, and Peter Hotez MD PhD, Dean of the National School for Tropical Medicine. Selection of trainees is performed by the Selection Committee, which includes the Executive Committee and three other program faculty. The training program for MD fellows includes research rotations to facilitate selection of a mentor. Both MD and PhD trainees have individual research committees, must prepare a written research proposal to be defended to the research committee, and have yearly reviews that include academic and career assessment. Both MD and PhD fellows are required to attend a monthly research-in-progress seminar series, a weekly journal club, and a yearly scientific social. All trainees must present at these meetings. The Adult and Pediatric Infectious Diseases Training Programs at BCM and other Departments participating in this NRSA have shown they can attract highly qualified, training- grant eligible postdoctoral trainee candidates including nearly two under-represented minority candidates per year. Twelve trainees have completed training supported by this Award, thus far. As a group, they have published a total of 118 peer-reviewed manuscripts resulting from their postdoctoral fellowship training (9.8 manuscripts per graduate; 59% first-authored by the graduate). In addition, these graduates have been awarded a total of $4.9M in external funding from the NIH and other competitive sources. All but one graduate continues to pursue an academic or industry-based infectious diseases career.