Training in Molecular Virology and Pathogenesis

分子病毒学和发病机制培训

• 批准号: 7864061
• 负责人: Colin R. Parrish
• 金额: $ 16.1万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7864061
• 关键词: Molecular Virology; Pathogenesis; Training

DESCRIPTION (provided by applicant): This application is to continue a training program in molecular virology and pathogenesis for 4 PhD students. This training program involves 9 virologists from Cornell University throughout the campus, including the Department of Microbiology and Immunology in the College of Veterinary Medicine, as well as the Departments of Molecular Biology and Genetics, and Plant Pathology, in addition to one virologist at the Boyce Thompson Institute. The common themes of the program are in molecular virology and the interactions between viruses and their host cells and tissues. The laboratories involved work on a variety of different viral systems, including herpesvirus replication and pathogenesis, influenza and coronavirus cell infection, parvovirus host range, reovirus and calicivirus cell replication mechanisms, retrovirus capsid assembly, baculovirus replication, and the interactions between plant viruses and their host cell transport pathways. These areas offer students many opportunities to examine the fundamental molecular mechanisms that control viral replication and the subsequent infection of the host. Students interested in virology are recruited through several graduate fields (campus-wide graduate programs) from throughout Cornell, which draw on large pools of well-qualified applicants with varying backgrounds. Students entering the program complete 3 rotations in different laboratories in their first year then choose a laboratory for their graduate training. This program supports students between Years 2 and 4 of their projects once they have chosen a laboratory and project in virology. Oversight of the student's training involves the student's mentor, the special committee with members from throughout the university, and the executive committee of the training program. A coordinated series of courses are available to the students, including two core courses in virology, and many others in relevant subjects which include various topics in immunology, biochemistry and molecular biology. Associated with the program are activities that involve faculty from throughout the university, including a weekly virology journal club, seminars in virology and related topics, and retreats in virology and infection biology and pathogenesis.

描述（由申请人提供）：本申请是为了继续进行分子病毒学和发病机制方面的4名博士生培训计划。该培训项目涉及9名来自康奈尔大学校园的病毒学家，包括兽医学院的微生物学和免疫学系、分子生物学和遗传学系、植物病理学系，以及博伊斯汤普森研究所的一名病毒学家。该计划的共同主题是分子病毒学和病毒与宿主细胞和组织之间的相互作用。这些实验室涉及多种不同的病毒系统，包括疱疹病毒的复制和发病机制、流感和冠状病毒细胞感染、细小病毒宿主范围、呼肠病毒和杯状病毒细胞复制机制、逆转录病毒衣壳组装、杆状病毒复制以及植物病毒与其宿主细胞运输途径之间的相互作用。这些领域为学生提供了许多机会来研究控制病毒复制和随后宿主感染的基本分子机制。对病毒学感兴趣的学生是通过康奈尔大学的几个研究生领域（校园研究生项目）招募的，这些领域吸引了大量具有不同背景的合格申请者。进入该项目的学生在第一年在不同的实验室完成3个轮岗，然后选择一个实验室进行研究生培训。一旦学生选择了病毒学的实验室和项目，这个项目将支持他们在二年级到四年级之间的项目。对学生培训的监督包括学生的导师、由整个大学的成员组成的特别委员会以及培训计划的执行委员会。为学生提供一系列协调的课程，包括两门病毒学核心课程，以及许多其他相关学科，包括免疫学，生物化学和分子生物学的各种主题。与该计划相关的活动涉及整个大学的教师，包括每周病毒学杂志俱乐部，病毒学和相关主题的研讨会，以及病毒学，感染生物学和发病机制的务静会。

项目成果

Career paths of alumni of the Cornell Leadership Program for Veterinary Students

康奈尔大学兽医学生领导力项目校友的职业道路

• 发表时间: 2008
• 期刊: The Veterinary Record
• 作者: David R. Fraser;D. McGregor;Y. Gröhn
• 通讯作者: Y. Gröhn

Chicken anemia virus.

鸡贫血病毒。

• DOI: 10.1007/978-3-540-70972-5_10
• 发表时间: 2009
• 期刊: Current topics in microbiology and immunology
• 作者: Schat,KA

Expression of the C-type lectins DC-SIGN or L-SIGN alters host cell susceptibility for the avian coronavirus, infectious bronchitis virus.

• DOI: 10.1016/j.vetmic.2012.01.011
• 发表时间: 2012-06-15
• 期刊: Veterinary microbiology
• 影响因子: 3.3
• 作者: Zhang Y;Buckles E;Whittaker GR
• 通讯作者: Whittaker GR

The capsid protein encoded by U(L)17 of herpes simplex virus 1 interacts with tegument protein VP13/14.

单纯疱疹病毒 1 型 U(L)17 编码的衣壳蛋白与被膜蛋白 VP13/14 相互作用。

• DOI: 10.1128/jvi.00277-10
• 发表时间: 2010
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Scholtes,LuellaD;Yang,Kui;Li,LucyX;Baines,JoelD
• 通讯作者: Baines,JoelD

Influenza entry pathways in polarized MDCK cells.

• DOI: 10.1016/j.bbrc.2014.05.095
• 发表时间: 2014-07-18
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Zhang, Yueting;Whittaker, Gary R.
• 通讯作者: Whittaker, Gary R.