Alzheimer's Disease Patient Registry (ADPR)

阿尔茨海默病患者登记处 (ADPR)

• 批准号: 7731683
• 负责人: Eric B Larson
• 金额: $ 244.91万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731683
• 关键词: Abbreviations; Address; Aging-Related Process; Albumins; Alzheimer' s Disease patient registry; Anticoagulation; Atrial Fibrillation; Autopsy; Biochemical; Blood Vessels; Brain; Clinical; Communities; Creatinine; Data; Data Set; Dementia; Development; Diabetes Mellitus; Disease; Dose; Dyslipidemias; Elderly; Equilibrium; Exercise; Functional disorder; Glomerular Filtration Rate; Goals; Hyperglycemia; Impaired cognition; Incidence; Individual; Insulin; Insulin Resistance; Investments; Joints; Kidney Diseases; Laboratories; Life; Link; Literature; Measurement; Measures; Medical Records; Microscopic; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Participant; Performance; Persons; Process; Psychometrics; Records; Renal function; Research Infrastructure; Research Personnel; Research Subjects; Resources; Risk; Risk Factors; Serum; Single Nucleotide Polymorphism; Societies; Syndrome; Testing; Time; Urine; Visit; Walking; Weight; aging brain; base; blood pressure regulation; cohort; depression; follow-up; frailty; genome-wide; grasp; high risk; improved; inflammatory marker; middle age; novel; oxidative damage; population based; post gamma-globulins; programs; research study

DESCRIPTION (provided by applicant): The overall goal of this project is to deepen our understanding of aging processes and the aging brain in a community-based population. Our projects are thematically linked to an overarching hypothesis based on previous results from our own studies and the literature: that microinfarcts are key pathophysiological processes in late life brain dysfunction. Aims 1 & 2 will test hypotheses regarding 4 late-life brain outcomes: 1) Development of dementia and AD; 2) Trajectories of global cognitive decline incorporating sophisticated modern psychometric analyses; 3) Standard microscopic neuropathological measures; and 4) Novel biochemical neuropathological markers, including soluble A(S oligomers, markers of regional oxidative damage, and inflammatory markers. Aim 1. Exploit unique clinical records to test hypotheses about the association between mid- and late-life micro- and macro-vascular conditions and late-life brain outcomes. Aim 1 will take advantage of the >117,000 person-years of medical record data available from the cohort. Aim la. Test hypotheses related to type 2 diabetes (DM). We will identify the independent and joint contributions of mid-life and late-life insulin resistance and hyperglycemia on late-life brain outcomes to determine whether these outcomes are best explained by insulin resistance, hyperglycemia, or both. Aim lb. Test hypotheses related to renal disease. We will determine whether mid-life and late-life renal function is associated with greater risk for late-life brain outcomes. Aim 1c. Test hypotheses related to atrial fibrillation (AF). We will determine whether AF is associated with higher risk for late-life brain outcomes, whether increased persistence and duration of AF convey additional increased risk, and the extent to which anticoagulation ameliorates risks associated with AF. Aim 2. Exploit unique ACT study research data to test hypotheses about the association between late-life measures of physical performance, frailty, and late-life brain outcomes. We will follow-up our preliminary finding that timed walk during life is associated with the presence of microinfarcts among autopsied participants to more fully test the hypotheses that decrements in timed walk and the development of frailty precede late-life brain outcomes. Aim 3. Continue to serve as a valuable scientific resource and improve infrastructure to facilitate external use of ACT data.

描述（由申请人提供）：该项目的总体目标是加深我们对社区人口老龄化过程和老龄化大脑的理解。我们的项目在主题上与基于我们自己的研究和文献的先前结果的总体假设相关联：微梗死是晚年脑功能障碍的关键病理生理过程。目的1和2将测试关于4种晚年大脑结果的假设：1）痴呆和AD的发展; 2）结合复杂的现代心理测量分析的整体认知下降轨迹; 3）标准显微镜神经病理学测量;和4）新的生化神经病理学标志物，包括可溶性A（S）寡聚体，区域氧化损伤标志物和炎症标志物。目标1。利用独特的临床记录来测试关于中晚期微血管和大血管状况与晚期大脑结果之间关联的假设。目标1将利用来自队列的> 117，000人-年的医疗记录数据。瞄准洛杉矶。2型糖尿病（DM）的发病机制我们将确定中年和晚年胰岛素抵抗和高血糖对晚年大脑结果的独立和联合贡献，以确定这些结果是否最好由胰岛素抵抗，高血糖或两者兼而有之来解释。瞄准磅。检验与肾脏疾病相关的假设。我们将确定中年和晚年肾功能是否与晚年大脑结局的更大风险相关。目标1c。测试与房颤（AF）相关的假设。我们将确定房颤是否与晚期脑结局的高风险相关，房颤持续时间和持续时间的增加是否会增加风险，以及抗凝治疗在多大程度上改善了房颤相关风险。利用独特的ACT研究数据来测试有关晚年身体表现指标、虚弱程度和晚年大脑结果之间关联的假设。我们将跟进我们的初步发现，即生活中定时行走与尸检参与者中微梗死的存在相关，以更充分地测试定时行走减少和虚弱发展先于晚年大脑结果的假设。目标3.继续作为宝贵的科学资源，并改善基础设施，以促进ACT数据的外部使用。