Human Subjects Core

人类受试者核心

• 批准号: 7877964
• 负责人: Robert D Frisina
• 金额: $ 10.68万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7877964
• 关键词: Age; Alzheimer' s Disease; Ataxia; Cognitive; Collaborations; Communication; Credentialing; Data; Databases; Degenerative Disorder; Faculty; Family; Goals; Grant; Growth; Guidelines; Hearing; Human; Individual; Informed Consent; Inherited; Laboratories; Medical; Motor; Neurologic; Patients; Physiological; Population; Procedures; Productivity; Protocols documentation; Records; Research; Research Personnel; Research Project Grants; Research Subjects; Schedule; Science; Screening procedure; Seasons; Sensorineural Hearing Loss; Sensory; Services; Structure; Students; Target Populations; Time; Training; Universities; Vision; human subject; nervous system disorder; novel; research study; tool

A variety of research projects within the Core-Center employ human subjects. The Human Subjects Core (HSC) greatly facilitates our collective research goals by centralizing a set of common procedures, operated by a seasoned staff that interact effectively with both the subjects and with faculty, students, and laboratory staff within the research studies supported by the Core. The Core provides several key services. First, the Core coordinates recruitment and screening of human subjects across research projects (normal and patient). This includes identifying subjects and obtaining informed consent, followed by basic medical and sensorimotor/neurologic exams, as well as physiologic and cognitive screening relevant to the populations targeted by Core studies. Populations now under study include normal subjects across a broad range of ages, subjects with specific neurological disorders (e.g. inherited ataxias, Alzheimer's and other degenerative diseases), and subjects with specific sensory loss (hearing, vision, vestibular), but otherwise healthy. Second, the Core coordinates scheduling and tracking across projects in order to maximize efficiency and convenience for subjects, investigators and staff. Further, the use of common subjects across studies supplies novel and paired observations that enhance productivity and stimulate new and collaborative research. Third, the Core maintains a powerful modern database that provides protected access to data and analytic tools for investigators and staff. This central service promotes new studies while making existing ones more efficient. Fourth, Core services include the coordination of protocol approvals, staff credential ing, and record keeping required of all human studies. The above services and tasks are made exceedingly efficient by a centralized structure orchestrated by a seasoned and trained staff. The benefits unload time and effort for faculty and staff to pursue more directly relevant research goals, and simultaneously catalyze new projects and collaborations. This is apparent in the growth of human studies in the Core-Center, including those by new faculty and ongoing ones alike.

核心中心内的各种研究项目都雇用了人类受试者。人类主体 CORE(HSC)通过集中一套通用程序，极大地促进了我们的集体研究目标， 由经验丰富的工作人员运营，与受试者以及教职员工、学生和 实验室工作人员在研究中心的支持下进行研究。核心提供几项关键服务。 首先，核心协调整个研究中人类受试者的招募和筛选 项目(正常和耐心)。这包括确定受试者和获得知情同意，随后 通过基础医学和感觉运动/神经学检查，以及相关的生理和认知筛查 核心研究的目标人群。目前正在研究的人群包括 年龄范围广泛，患有特定神经疾病的受试者(例如遗传性共济失调、阿尔茨海默氏症和 其他退行性疾病)和有特定感觉丧失(听力、视力、前庭)的受试者，但 其他方面都很健康。 第二，核心协调跨项目的计划和跟踪，以便最大限度地 为受试者、调查人员和工作人员提供高效和便利。此外，常见主语的使用 研究提供了新的和配对的观察，以提高工作效率并激发新的和 合作研究。 第三，核心维护一个强大的现代数据库，提供对数据的保护访问和 调查人员和工作人员的分析工具。这一中心服务促进了新的研究，同时使现有的 效率更高的。 第四，核心服务包括协调协议审批、工作人员凭据和 所有人体研究都要求保存记录。 上述服务和任务由以下人员协调的集中式结构极具效率 经验丰富、训练有素的员工。这些好处为教职员工节省了时间和精力，使他们可以更直接地追求 相关的研究目标，同时催化新的项目和合作。这一点在 核心中心人类研究的增长，包括新教员和正在进行的教员的研究。