Human Subjects Core

人类受试者核心

基本信息

批准号：
8375960
负责人：
Robert D Frisina
金额：
$ 14.44万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-23 至 2015-06-30
项目状态：
已结题

项目摘要

A variety of research projects within the Core-Center employ human subjects. The Human Subjects Core (HSC) greatly facilitates our collective research goals by centralizing a set of common procedures, operated by a seasoned staff that interact effectively with both the subjects and with faculty, students, and laboratory staff within the research studies supported by the Core. The Core provides several key services. First, the Core coordinates recruitment and screening of human subjects across research projects (normal and patient). This includes identifying subjects and obtaining informed consent, followed by basic medical and sensorimotor/neurologic exams, as well as physiologic and cognitive screening relevant to the populations targeted by Core studies. Populations now under study include normal subjects across a broad range of ages, subjects with specific neurological disorders (e.g. inherited ataxias, Alzheimer's and other degenerative diseases), and subjects with specific sensory loss (hearing, vision, vestibular), but otherwise healthy. Second, the Core coordinates scheduling and tracking across projects in order to maximize efficiency and convenience for subjects, investigators and staff. Further, the use of common subjects across studies supplies novel and paired observations that enhance productivity and stimulate new and collaborative research. Third, the Core maintains a powerful modern database that provides protected access to data and analytic tools for investigators and staff. This central service promotes new studies while making existing ones more efficient. Fourth, Core services include the coordination of protocol approvals, staff credential ing, and record keeping required of all human studies. The above services and tasks are made exceedingly efficient by a centralized structure orchestrated by a seasoned and trained staff. The benefits unload time and effort for faculty and staff to pursue more directly relevant research goals, and simultaneously catalyze new projects and collaborations. This is apparent in the growth of human studies in the Core-Center, including those by new faculty and ongoing ones alike.

核心中心内的各种研究项目采用人类受试者。人类主题核心（HSC）通过集中一组共同程序，极大地促进了我们的集体研究目标，由经验丰富的员工经营，与受试者以及教职员工，学生和核心支持的研究中的实验室人员。核心提供了几个关键服务。首先，核心协调在研究中招募和筛选人类受试者项目（正常和患者）。这包括识别主题并获得知情同意，遵循通过基本的医学和感觉运动/神经学检查，以及生理和认知筛查相关核心研究针对的人群。现在正在研究的人群包括跨A的正常受试者广泛的年龄，患有特定神经系统疾病的受试者（例如，共济失调，阿尔茨海默氏症和其他退化性疾病），以及具有特定感觉丧失（听力，视觉，前庭）的受试者，但否则健康。其次，核心坐标跨项目进行调度和跟踪，以最大程度地提高对受试者，调查人员和员工的效率和便利性。此外，跨越常见主题研究提供了新颖和配对的观察结果，可提高生产率并刺激新的观测协作研究。第三，核心维护一个强大的现代数据库，可提供受保护的数据访问，研究人员和员工的分析工具。这项中央服务促进了新的研究，同时进行现有一个更有效。第四，核心服务包括协议批准的协调，员工证书以及所有人类研究都需要记录保留。上述服务和任务由由集中式结构策划的集中式结构非常有效经验丰富训练的员工。收益为教师和教职员工更直接地追求时间和精力相关的研究目标，同时催化新项目和合作。这在人类研究中核心中心研究的增长，包括新教师和正在进行的教师。