Born in Bradford: environmental exposure and birth weight

出生于布拉德福德：环境暴露和出生体重

• 批准号: NE/E008844/1
• 负责人: Mireille Toledano
• 金额: $ 15.81万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FE008844%2F1
• 关键词: Born; Bradford; environmental; exposure; birth

Birth weight reflects intrauterine growth and wellbeing and is recognised globally as an indicator of perinatal and infant health. A number of studies have suggested that occupation, air pollution and chlorination by-products in drinking water may be associated with low birth weight/intra uterine growth retardation (Nieuwenhuijsen et al 2000, Sram et al 2005, Farrow et al 1998, Chia et al 2004, Rylander and Kallen 2005), but the evidence is inconclusive, partly as a result of limited exposure assessments in the epidemiological studies that have been conducted. A large prospective birth cohort study is required to provide conclusive evidence about the link between occupation, chlorination by-products and air pollution on birth weight. The overall aim of this study is to bring together a multi-disciplinary team of physicians, epidemiologists, geneticists, environmental scientists, social scientists and statistical modellers to build capacity and lay the ground work for further studies to investigate the relationship, if any, between occupational factors, traffic related air pollution and chlorination disinfection by-products (DBPs) in drinking water and intra uterine growth retardation/low birth weight, taking into account known potential confounders such as smoking and ethnicity in the Born in Bradford study of 10,000 pregancies. The main focus of the work is the collection of information for the validation of exposure estimates, together with the initiation of data collection for the exposure modelling and preparing a strategy for linking them to health data.

出生体重反映了胎儿宫内的发育和健康状况，是全球公认的围产期和婴儿健康指标。一些研究表明，职业、空气污染和饮用水氯化副产品可能与出生体重低/宫内发育迟缓有关（Nieuwenhuijsen等2000，Sram等2005，Farrow等1998，Chia等2004，Rylander和Kallen 2005），但证据不确定，部分原因是所进行的流行病学研究中的接触评估有限。需要进行一项大规模的前瞻性出生队列研究，以提供关于职业、氯化副产品和空气污染与出生体重之间联系的结论性证据。这项研究的总体目标是汇集一个由医生、流行病学家、遗传学家、环境科学家、社会科学家和统计建模者组成的多学科团队，以建设能力，并为进一步研究奠定基础，以调查职业因素、与交通有关的空气污染和饮用水中的氯化消毒副产物以及子宫内发育迟缓/出生体重低，考虑到已知的潜在混杂因素，如吸烟和种族在布拉德福德出生的10,000例孕妇的研究。这项工作的主要重点是收集信息，以验证接触估计数，同时开始收集接触建模的数据，并制定一项将其与健康数据联系起来的战略。

项目成果

Birth Weight, Ethnicity, and Exposure to Trihalomethanes and Haloacetic Acids in Drinking Water during Pregnancy in the Born in Bradford Cohort.

• DOI: 10.1289/ehp.1409480
• 发表时间: 2016-05
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Smith RB;Edwards SC;Best N;Wright J;Nieuwenhuijsen MJ;Toledano MB
• 通讯作者: Toledano MB

P-162 Tap Water Consumption, Showering, Bathing and Swimming during Pregnancy in the Born in Bradford Birth Cohort

P-162 布拉德福德出生队列中出生的婴儿在怀孕期间的自来水消耗量、淋浴、沐浴和游泳

• DOI: 10.1097/01.ede.0000417165.72087.ed
• 发表时间: 2012
• 期刊: Epidemiology
• 影响因子: 5.4
• 作者: Smith R

Exposure to Disinfection By-products During Pregnancy

怀孕期间接触消毒副产品

• DOI: 10.1097/01.ede.0000392043.30688.93
• 发表时间: 2011
• 期刊: Epidemiology
• 影响因子: 5.4
• 作者: Smith R

O-171 Exposure to Trichloroacetic Acid via Drinking Water during Pregnancy - Insights from a Nested Biomarker Study

O-171 怀孕期间通过饮用水接触三氯乙酸 - 嵌套生物标志物研究的见解

• DOI: 10.1097/01.ede.0000416828.43877.34
• 发表时间: 2012
• 期刊: Epidemiology
• 影响因子: 5.4
• 作者: Smith R

The Relationship between MX [3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone], Routinely Monitored Trihalomethanes, and Other Characteristics in Drinking Water in a Long-Term Survey.

长期调查中 MX [3-氯-4-（二氯甲基）-5-羟基-2(5H)-呋喃酮]、常规监测的三卤甲烷以及饮用水中其他特征之间的关系。

• DOI: 10.1021/es5062006
• 发表时间: 2015
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: Smith RB