Cancer Stem Cells and Radiotherapy: New Approaches to Radiosensitization

描述（由申请人提供）：斯坦福大学癌症中心主要致力于开发基于最佳科学的癌症新疗法。最近的数据表明，许多实体瘤含有能够在免疫缺陷小鼠中增殖肿瘤的细胞亚群，而大多数肿瘤细胞不能这样做。这些肿瘤起始细胞或肿瘤干细胞具有与肿瘤主体不同的性质。癌症中心寻求招募一名具有肿瘤干细胞生物学专业知识的医生科学家，他们将能够开发基于使肿瘤干细胞对辐射诱导的细胞死亡敏感的能力的创新癌症治疗方法。这个人将在放射肿瘤学的董事会资格，并将有丰富的实验室经验，使他/她具有很强的竞争力的R 01资金。已经开始搜索，并确定了一名符合这些资格的潜在候选人。一个由米切尔博士担任癌症中心主任、放射肿瘤学和生物化学主席以及一名高级癌症干细胞医生科学家组成的指导委员会已经成立。斯坦福大学将于2010年完工的一座新的癌症中心/干细胞大楼将为这次招募提供空间。基础和临床两方面的研究环境 候选人的职业发展是一流的，候选人将有机会通过跨学科的nci资助的癌症生物学计划的研究生，以及通过礼貌 在生物化学系任职。这名教师将有80%的保护时间， 研究和癌症中心和放射肿瘤学系承诺支持他/她的第三年和第四年的教师任命在一个水平相当于由该补助金资助的候选人。我们预计，在这一领域的成功招募将大大加强临床研究，是在斯坦福大学癌症中心内进行的基础上产生的假设，从增加了解的细胞，引发人类癌症的生物学。

DESCRIPTION (Provided by the applicant): The Stanford Cancer Center has a major interest in developing new treatments for cancer that are based on the best science. Recent data indicate that many solid tumors contain a subset of cells that are capable of propagating that tumor in immunodeficient mice, whereas the majority of tumor cells are incapable of doing so. These tumor-initiating or tumor stem cells have properties that differ from those in the bulk of the tumor. The Cancer Center seeks to recruit a physician scientist with expertise in the biology of tumor stem cells who will be able to develop innovative cancer treatments based on the ability to sensitize tumor Stem cells to radiation-induced cell death. This individual will be board eligible in radiation oncology and will have had extensive laboratory experience that will enable him/her to be highly competitive for R01 funding. A search has been initiated and one prospective candidate identified who meets these qualifications. A mentoring committee consisting of Dr. Mitchell as Cancer Center Director, the Chairs of Radiation Oncology and Biochemistry, and a senior cancer stem cell physician scientist has been put together. Space for this recruitment will be available in a new Cancer Center/Stem Cell Building at Stanford that will be completed in 2010. The research environment for both the basic and clinical aspects of the candidate's career development is superb and the candidate will have access to graduate students through the interdisciplinary NCI-funded cancer biology program, as well through a courtesy appointment in the Department of Biochemistry. This faculty member will have 80% protected time for research and the Cancer Center and Department of Radiation Oncology commit to support this candidate for his/her third and fourth years of faculty appointment at a level equivalent to that funded by this grant. We anticipate that a successful recruitment in this area will greatly enhance the clinical research that is carried out within the Stanford Cancer Center based on hypotheses generated from an increased understanding of the biology of cells that initiate human cancers.