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Cancer Stem Cells and Radiotherapy: New Approaches to Radiosensitization

癌症干细胞和放射治疗：放射增敏的新方法

基本信息

批准号：
7939668
负责人：
BEVERLY S. MITCHELL
金额：
$ 80.17万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7939668
关键词：
Appointment Area Basic Science Biochemistry Biology Cancer Biology Cancer Center Cancer Etiology Cancer Patient Cell Death Cells Cellular biology Clinic Clinical Clinical Investigator Clinical Research Collaborations Commit Data Development Discipline Doctor of Philosophy Environment Faculty Funding Grant Growth Human Hypoxia Image Immunodeficient Mouse Individual Joints Knowledge Laboratories Lead Malignant Neoplasms Mentors Mission NCI Center for Cancer Research Pathway interactions Physicians Proliferating Property Radiation Radiation Oncologist Radiation Oncology Radiation therapy Radiobiology Radiosensitization Recruitment Activity Research Resistance Science Scientific Advances and Accomplishments Scientist Solid Neoplasm Stem cells Time Toxic effect Training Tumor Biology Tumor Stem Cells United States National Institutes of Health Ursidae Family base cancer diagnosis cancer prevention cancer research center director cancer stem cell cancer therapy career development cell determination chemotherapy experience graduate student improved innovation interest killings meetings member neoplastic cell novel novel strategies oncology programs prospective public health relevance research study self-renewal stem cell biology tumor

项目摘要

DESCRIPTION (Provided by the applicant): The Stanford Cancer Center has a major interest in developing new treatments for cancer that are based on the best science. Recent data indicate that many solid tumors contain a subset of cells that are capable of propagating that tumor in immunodeficient mice, whereas the majority of tumor cells are incapable of doing so. These tumor-initiating or tumor stem cells have properties that differ from those in the bulk of the tumor. The Cancer Center seeks to recruit a physician scientist with expertise in the biology of tumor stem cells who will be able to develop innovative cancer treatments based on the ability to sensitize tumor Stem cells to radiation-induced cell death. This individual will be board eligible in radiation oncology and will have had extensive laboratory experience that will enable him/her to be highly competitive for R01 funding. A search has been initiated and one prospective candidate identified who meets these qualifications. A mentoring committee consisting of Dr. Mitchell as Cancer Center Director, the Chairs of Radiation Oncology and Biochemistry, and a senior cancer stem cell physician scientist has been put together. Space for this recruitment will be available in a new Cancer Center/Stem Cell Building at Stanford that will be completed in 2010. The research environment for both the basic and clinical aspects of the candidate's career development is superb and the candidate will have access to graduate students through the interdisciplinary NCI-funded cancer biology program, as well through a courtesy appointment in the Department of Biochemistry. This faculty member will have 80% protected time for research and the Cancer Center and Department of Radiation Oncology commit to support this candidate for his/her third and fourth years of faculty appointment at a level equivalent to that funded by this grant. We anticipate that a successful recruitment in this area will greatly enhance the clinical research that is carried out within the Stanford Cancer Center based on hypotheses generated from an increased understanding of the biology of cells that initiate human cancers.

描述(由申请人提供)：斯坦福癌症中心对开发基于最好的科学的癌症新疗法非常感兴趣。最近的数据表明，许多实体肿瘤含有能够在免疫缺陷小鼠体内繁殖肿瘤的细胞亚群，而大多数肿瘤细胞不能这样做。这些启动肿瘤的干细胞或肿瘤干细胞具有与肿瘤大部分不同的特性。癌症中心寻求招聘一名在肿瘤干细胞生物学方面具有专业知识的内科科学家，他将能够基于使肿瘤干细胞对辐射诱导的细胞死亡敏感的能力开发创新的癌症治疗方法。此人将获得放射肿瘤学董事会资格，并将拥有丰富的实验室经验，这将使他/她在R01资金方面具有很强的竞争力。已经启动了一项搜索，并确定了一名符合这些条件的潜在候选人。一个由米切尔博士担任癌症中心主任，放射肿瘤学和生物化学主任，以及一名资深癌症干细胞内科科学家组成的指导委员会已经成立。斯坦福大学的一座新的癌症中心/干细胞大楼将于2010年完工，将为此次招聘提供空间。基础和临床两方面的研究环境候选人的职业发展非常出色，候选人将有机会通过NCI资助的跨学科癌症生物学项目以及礼貌地接触到研究生在生物化学系任职。这位教职员工将有80%的保护时间癌症研究中心和放射肿瘤学系承诺支持这位候选人在他/她的第三年和第四年的教职任命，水平相当于这笔拨款资助的水平。我们预计，这一领域的成功招聘将极大地加强斯坦福癌症中心内进行的临床研究，这些研究基于对引发人类癌症的细胞生物学的更多了解而产生的假设。