Cancer Stem Cells and Radiotherapy: New Approaches to Radiosensitization

描述（由申请人提供）：斯坦福癌症中心对开发基于最佳科学的癌症新疗法非常感兴趣。最近的数据表明，许多实体瘤含有能够在免疫缺陷小鼠中繁殖肿瘤的细胞亚群，而大多数肿瘤细胞不能这样做。这些肿瘤起始细胞或肿瘤干细胞具有不同于大部分肿瘤细胞的特性。癌症中心寻求一名具有肿瘤干细胞生物学专业知识的内科科学家，他将能够基于使肿瘤干细胞对辐射诱导的细胞死亡敏感的能力开发创新的癌症治疗方法。该个人将符合放射肿瘤学的董事会资格，并将具有丰富的实验室经验，这将使他/她在R01资助中具有很强的竞争力。一项搜索已经启动，并确定了一名符合这些条件的潜在候选人。一个指导委员会由米切尔博士（癌症中心主任）、放射肿瘤学和生物化学主任以及一名高级癌症干细胞内科科学家组成。本次招聘将在斯坦福大学的一个新的癌症中心/干细胞大楼中进行，该大楼将于2010年完工。基础和临床两方面的研究环境

DESCRIPTION (Provided by the applicant): The Stanford Cancer Center has a major interest in developing new treatments for cancer that are based on the best science. Recent data indicate that many solid tumors contain a subset of cells that are capable of propagating that tumor in immunodeficient mice, whereas the majority of tumor cells are incapable of doing so. These tumor-initiating or tumor stem cells have properties that differ from those in the bulk of the tumor. The Cancer Center seeks to recruit a physician scientist with expertise in the biology of tumor stem cells who will be able to develop innovative cancer treatments based on the ability to sensitize tumor Stem cells to radiation-induced cell death. This individual will be board eligible in radiation oncology and will have had extensive laboratory experience that will enable him/her to be highly competitive for R01 funding. A search has been initiated and one prospective candidate identified who meets these qualifications. A mentoring committee consisting of Dr. Mitchell as Cancer Center Director, the Chairs of Radiation Oncology and Biochemistry, and a senior cancer stem cell physician scientist has been put together. Space for this recruitment will be available in a new Cancer Center/Stem Cell Building at Stanford that will be completed in 2010. The research environment for both the basic and clinical aspects of the candidate's career development is superb and the candidate will have access to graduate students through the interdisciplinary NCI-funded cancer biology program, as well through a courtesy appointment in the Department of Biochemistry. This faculty member will have 80% protected time for research and the Cancer Center and Department of Radiation Oncology commit to support this candidate for his/her third and fourth years of faculty appointment at a level equivalent to that funded by this grant. We anticipate that a successful recruitment in this area will greatly enhance the clinical research that is carried out within the Stanford Cancer Center based on hypotheses generated from an increased understanding of the biology of cells that initiate human cancers.