Biomedical Informatics

生物医学信息学

• 批准号: 7715184
• 负责人: PHILIP R.O. PAYNE
• 金额: $ 14.58万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715184
• 关键词: Address; Area; Basic Science; Biostatistics Core; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Comprehensive Cancer Center; Computer software; Data; Data Analyses; Data Set; Data Sources; Database Management Systems; Databases; Development; Ensure; Epigenetic Process; General Population; Genes; Genetic; Health Benefit; Instruction; Internet; Knowledge; Methods; Ohio; Online Systems; Ontology; Operative Surgical Procedures; Participant; Pharmaceutical Chemistry; Pilot Projects; Program Development; Public Health; Reproduction spores; Research; Research Personnel; Resource Sharing; Risk; Science; Secure; Services; Structure; Surveys; System; Technology; Therapeutic; Tissues; Universities; Update; Work; biomedical informatics; caGrid; catalyst; clinical application; clinical practice; data exchange; electronic data; interoperability; lenalidomide; leukemia; leukemia tissue bank; member; middleware; news; research study; silvestrol; tool; translational study; web site

The primary objective of the Biomedical Informatics Core (BMIC) is to facilitate the collecfion, management, ntegration, and analysis of a complete spectrum of information types required for the efficient operation of the SPORE'S projects, pilots, and other cores. Examples of these informafion types include stmctured and semi-structured data sets resulting from: 1) experimental studies; 2) biostatistical analyses; 3) fissue core and administrative operations; 4) shared resource services; and 5) the asynchronous collaborafion of SPORE participants. We will achieve this objecfive using a combinafion biomedical informafics best practices and advanced technologies already in use or under development within The Ohio State University (OSU) Department of Biomedical Informafics (OSU-BMI) and The Ohio State University Comprehensive Cancer Center (OSU-CCC). Such technologies include: 1) the service-oriented caGrid middleware for electronic data interchange between heterogeneous biomedical data sources and analytical services; 2) advanced database management systems optimized for the storage and query of rapidly evolving biomedical data sets; 3) centralized ontology services and ontology-anchored knowledge discovery/management tools; 4) mulfiple task-specific web-portal applicafions that support the discovery, integration, and analysis of large scale, multi-dimensional data sets; and 5) web-based collaborative team-science tools. We envision the BMIC as being the central information coordination "hub" of the SPORE. In order to achieve these objectives, the specific aims of the biomedical informafics core are to: 1) develop and support extensible database management systems for use by SPORE participants; 2) enable electronic data interchange between SPORE-related data sources; 3) support task-specific web portal applications that allow end users to discover, integrate, and analyze SPORE-related data sources; 4) support the execution of SPORE-related clinical trials through the facilitation of access to the OSU-CCC's enterprise-grade clinical trials management system; and 5) implement and support a collaborative web portal intended to serve as a medium for both team-science and public disseminafion acfivities. RELEVANCE (See instructions): The Biomedical Informafics Core's (BMIC) activifies as part of this SPORE will cover a wide spectrum, from the facilitafion of high-throughput data analyses to the provision of tools to enable the collaboration of temporally or geographically distributed investigators. As such, the BMIC will serve as a catalyst for the rapid and efficient conduct of translational studies, with the effect of accelerating the translafion and dissemination of basic science discoveries into clinical practice and ultimately public health benefits.

生物医学信息学核心（BMIC）的主要目标是促进收集、管理、 整合和分析高效运行所需的完整信息类型 SPORE 的项目、试点和其他核心。这些信息类型的示例包括结构化和 半结构化数据集源自：1）实验研究； 2）生物统计分析； 3) 组织核心 和行政运作； 4）共享资源服务； 5）异步协作 孢子参与者。我们将最好地结合生物医学信息学来实现这一目标 俄亥俄州立大学已在使用或正在开发的实践和先进技术 (OSU) 生物医学信息学系 (OSU-BMI) 和俄亥俄州立大学综合分校 癌症中心 (OSU-CCC)。此类技术包括： 1) 面向服务的 caGrid 中间件 异构生物医学数据源和分析服务之间的电子数据交换； 2） 先进的数据库管理系统针对快速发展的生物医学的存储和查询进行了优化 数据集； 3）集中式本体服务和本体锚定的知识发现/管理工具； 4) 多个特定于任务的门户应用程序，支持大型数据的发现、集成和分析 规模化、多维度的数据集； 5) 基于网络的协作团队科学工具。我们设想 BMIC 是 SPORE 的中央信息协调“枢纽”。为了实现这些 目标，生物医学信息学核心的具体目标是：1）开发和支持可扩展的 供 SPORE 参与者使用的数据库管理系统； 2) 实现电子数据交换 SPORE 相关数据源之间； 3) 支持允许最终用户的特定任务的门户网站应用程序 发现、集成和分析 SPORE 相关数据源； 4）支持SPORE相关的执行 通过促进访问 OSU-CCC 的企业级临床试验管理来进行临床试验 系统; 5) 实施和支持一个协作门户网站，旨在作为双方的媒介 团队科学和公共传播活动。 相关性（参见说明）： 作为该 SPORE 的一部分，生物医学信息核心 (BMIC) 将涵盖广泛的领域，从 促进高通量数据分析，提供工具以实现协作 时间或地理上分布的调查员。因此，BMIC 将成为推动 快速有效地进行转化研究，具有加速转化和转化的效果 将基础科学发现传播到临床实践并最终造福公众健康。