Biomedical Informatics

生物医学信息学

• 批准号: 8521134
• 负责人: PHILIP R.O. PAYNE
• 金额: $ 12.28万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8521134
• 关键词: Address; Area; Basic Science; Clinical Research; Clinical Trials; Collaborations; Collection; Comprehensive Cancer Center; Computer software; Data; Data Analyses; Data Set; Data Sources; Database Management Systems; Databases; Development; Ensure; General Population; Health Benefit; Internet; Knowledge Discovery; Methods; Ohio; Online Systems; Ontology; Participant; Pilot Projects; Program Development; Public Health; Research; Research Personnel; Resource Sharing; Science; Secure; Services; Structure; Surveys; System; Technology; Therapeutic; Tissues; Translations; Universities; Update; Work; biomedical informatics; caGrid; catalyst; clinical practice; data exchange; electronic data; interoperability; leukemia; member; middleware; news; operation; research study; tool; translational study; web site

The primary objective of the Biomedical Informatics Core (BMIC) is to facilitate the collection, management, integration, and analysis of a complete spectrum of information types required for the efficient operation of the SPORE'S projects, pilots, and other cores. Examples of these information types include structured and semi-structured data sets resulting from: 1) experimental studies; 2) biostatistical analyses; 3) tissue core and administrative operations; 4) shared resource services; and 5) the asynchronous collaboration of SPORE participants. We will achieve this objective using a combination biomedical informatics best practices and advanced technologies already in use or under development within The Ohio State University (OSU) Department of Biomedical Informatics (OSU-BMI) and The Ohio State University Comprehensive Cancer Center (OSU-CCC). Such technologies include: 1) the service-oriented caGrid middleware for electronic data interchange between heterogeneous biomedical data sources and analytical services; 2) advanced database management systems optimized for the storage and query of rapidly evolving biomedical data sets; 3) centralized ontology services and ontology-anchored knowledge discovery/management tools; 4) multiple task-specific web-portal applications that support the discovery, integration, and analysis of large scale, multi-dimensional data sets; and 5) web-based collaborative team-science tools. We envision the BMIC as being the central information coordination "hub" of the SPORE. In order to achieve these objectives, the specific aims of the biomedical informatics core are to: 1) develop and support extensible database management systems for use by SPORE participants; 2) enable electronic data interchange between SPORE-related data sources; 3) support task-specific web portal applications that allow end users to discover, integrate, and analyze SPORE-related data sources; 4) support the execution of SPORE-related clinical trials through the facilitation of access to the OSU-CCC's enterprise-grade clinical trials management system; and 5) implement and support a collaborative web portal intended to serve as a medium for both team-science and public dissemination activities.

生物医学信息学核心（BMIC）的主要目标是促进SPORE项目、试点和其他核心有效运作所需的完整信息类型的收集、管理、集成和分析。这些信息类型的例子包括：1)实验研究产生的结构化和半结构化数据集；2)生物统计分析；3)组织核心和行政操作；4)共享资源服务；5)《孢子》参与者的异步协作。我们将结合生物医学信息学的最佳实践和俄亥俄州立大学生物医学信息系（OSU- bmi）和俄亥俄州立大学综合癌症中心（OSU- ccc）已经使用或正在开发的先进技术来实现这一目标。这些技术包括：1)面向服务的caGrid中间件，用于异构生物医学数据源和分析服务之间的电子数据交换；2)先进的数据库管理系统，为快速发展的生物医学数据集的存储和查询优化；3)集中式本体服务和基于本体的知识发现/管理工具；4)支持发现、集成和分析大规模多维数据集的多任务门户网站应用程序；5)基于网络的协作团队科学工具。我们设想BMIC将成为《孢子》的中央信息协调“枢纽”。为了实现这些目标，生物医学信息学核心的具体目标是：1)开发和支持可扩展的数据库管理系统，供SPORE参与者使用；2)实现《孢子》相关数据源之间的电子数据交换；3)支持特定任务的web门户应用程序，允许最终用户发现、集成和分析与spore相关的数据源；4)通过接入企业级临床试验管理系统，支持开展spore相关临床试验；5)实施和支持一个协作门户网站，作为团队科学和公共传播活动的媒介。