Re-engineering the CRC Integrated Information Management System

描述(由申请人提供)：摘要/摘要拟议的项目重新设计CLL研究联盟综合信息管理系统的目标是通过采用和使用开源、基于标准的数据存储库、交换平台和分析工具来提高慢性淋巴细胞白血病(CLL)研究联盟(CRC)的整体翻译研究能力。这些组件的使用最终旨在支持高通量、多维生物医学数据的发现、集成、分析、存储和传播，以支持转换假设的发现和测试。这一目标将通过对现有CRC综合信息管理系统(CIMS)进行有针对性的再设计方案来实现，其目标是：1)将数据储存库和基于网络的接口应用程序转移到先进的开放源码数据库管理系统和企业信息门户平台；2)开发和使用将使CIMS和NCI-EVS之间实现语义互操作性的本体论结构，以及将利用该本体论的符合caGrid的数据交换应用程序，这将共同使CIMS与caGrid和更广泛的caBIG环境相结合；以及3)扩展CIMS数据储存库模型和相关接口应用程序，以便通过使用caBIG开发的软件组件来支持高吞吐量、多维数据集的收集、集成和分析，从而利用由上述目标提供的与这些组件的互操作性。此外，我们打算通过开放源码分发所有与项目相关的软件组件的过程，将项目产生的研究产品提供给更广泛的生物医学研究社区。这一最终目标旨在支持类似项目和计划中类似翻译研究信息管理平台的快速发展。该项目的成功将得益于以下方面的独特组合：1)CRC内部强大和成熟的信息管理系统以及相关的开发和管理专业知识；2)申请组织内已有的先进数据管理和网格计算中间件开发专业知识和产品；以及3)CRC调查员社区和研究人员对执行此项目的坚定承诺。叙述拟议的项目重新设计慢性淋巴细胞白血病研究联盟综合信息管理系统将提高慢性淋巴细胞白血病研究联盟(CRC)进行翻译研究的能力，以确定和评估慢性淋巴细胞白血病的治疗策略。慢性淋巴细胞白血病是美国最常见的成人白血病。CRC特别适合于进行所需的表型生物标记图谱研究，以开发和验证CLL的新生物模型(包括能够进行适应性治疗的预测性生物标记)和疾病的治疗方法。因此，提供更好的基础设施来进行这类研究将直接影响这类活动的速度、效率和质量，从而增加改善被诊断为慢性淋巴细胞性白血病患者的健康的机会。

DESCRIPTION (provided by applicant): Summary/Abstract The goal of the proposed project Re-engineering the CLL Research Consortium Integrated Information Management System is to increase the overall translational research capacity of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) through the adoption and use of open-source, standards based data repositories, interchange platforms, and analysis tools. The use of such components is ultimately intended to support the discovery, integration, analysis, storage, and dissemination of high-throughput, multi-dimensional biomedical data in support of translational hypothesis discovery and testing. This goal will be achieved through a targeted program of re-engineering of the existing CRC Integrated Information Management System (CIMS) that will have as its aims: 1) the migration of data repositories and web-based interface applications to an advanced, open-source database management system and enterprise information portal platform; 2) the development and use of both an ontology construct that will enable semantic interoperability between CIMS and the NCI-EVS and a caGrid compliant data interchange application that will utilize that ontology, which collectively will enable the integration of CIMS with caGrid and the broader caBIG environment; and 3) the extension of the CIMS data repository model and associated interface applications in order to support the collection, integration, and analysis of high-throughput, multi-dimensional data sets through a the use of caBIG developed software components, leveraging the interoperability with those components afforded by the preceding aims. In addition, we intend to make the research products generated by the project available to the broader biomedical research community through a process of open-source distribution of all project-related software components. This final aim is intended to support the rapid development of similar translational research information management platforms in analogous projects and programs. The success of this project will be afforded through the unique combination of: 1) a robust and mature information management system and associated development and management expertise within the CRC; 2) the advanced data management and grid-computing middleware development expertise and products already resident within the applicant organization; and 3) the strong commitment of the CRC investigator community and research staff to the execution of this project. Narrative The proposed project Re-engineering the CLL Research Consortium Integrated Information Management System will increase the ability of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) to conduct translational studies intended to identify and evaluate curative strategies for CLL, the most prevalent form of adult Leukemia in the United States. The CRC is uniquely suited to conduct the types of phenotype bio-marker mapping studies required to develop and validate both novel biological models of CLL (including predictive bio- markers capable of enabling adaptive therapy) and therapeutic approaches to the disease. Therefore, the provision of an improved infrastructure to conduct such studies should have a direct impact of the speed, efficiency, and quality of such activities, thus increase the opportunity to improve the health of patients diagnosed with CLL.