Re-engineering the CRC Integrated Information Management System

重组CRC综合信息管理系统

• 批准号: 7800313
• 负责人: PHILIP R.O. PAYNE
• 金额: $ 31.5万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7800313
• 关键词: Adoption; Automation; Basic Science; Biochemical; Biological Models; Biomedical Research; Boston; California; Cancer Center; Chromosome abnormality; Chronic Lymphocytic Leukemia; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Collection; Communities; Computer software; Dana-Farber Cancer Institute; Data; Data Analyses; Data Collection; Data Set; Data Sources; Data Storage and Retrieval; Database Management Systems; Databases; Development; Diagnosis; Disease; Doctor of Medicine; Electronic Health Record; Electronics; Engineering; Environment; Fluorescent in Situ Hybridization; Funding; Gene Expression; Genetic; Goals; Health; Immunologics; Immunophenotyping; Informatics; Information Management; Institutes; Internet; Knowledge; London; Long Island; Longitudinal Studies; Mails; Management Information Systems; Maps; Massachusetts; Measures; Medical Research; Medical center; Methods; Minnesota; Modality; Modeling; Molecular; New York; Ohio; Ontology; Participant; Patients; Phase; Phenotype; Process; Protocol Compliance; Protocols documentation; Research; Research Infrastructure; Research Personnel; Resources; Science; Semantics; Services; Site; Specimen; Speed; Staging; System; Technology; Testing; Texas; Therapeutic; Time; Tissue Banking; Tissue Banks; Tissue Sample; Tissues; Translational Research; United Kingdom; United States; United States National Institutes of Health; Universities; Vocabulary; abstracting; adult leukemia; base; biomedical informatics; caGrid; cancer Biomedical Informatics Grid; cluster computing; data management; data mining; data sharing; design; electronic data; falls; follower of religion Jewish; high throughput analysis; improved; instrument; instrumentation; interoperability; middleware; migration; novel; open source; operation; programs; research and development; response; satisfaction; software development; software systems; success; tool; translational study; web based interface

DESCRIPTION (provided by applicant): Summary/Abstract The goal of the proposed project Re-engineering the CLL Research Consortium Integrated Information Management System is to increase the overall translational research capacity of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) through the adoption and use of open-source, standards based data repositories, interchange platforms, and analysis tools. The use of such components is ultimately intended to support the discovery, integration, analysis, storage, and dissemination of high-throughput, multi-dimensional biomedical data in support of translational hypothesis discovery and testing. This goal will be achieved through a targeted program of re-engineering of the existing CRC Integrated Information Management System (CIMS) that will have as its aims: 1) the migration of data repositories and web-based interface applications to an advanced, open-source database management system and enterprise information portal platform; 2) the development and use of both an ontology construct that will enable semantic interoperability between CIMS and the NCI-EVS and a caGrid compliant data interchange application that will utilize that ontology, which collectively will enable the integration of CIMS with caGrid and the broader caBIG environment; and 3) the extension of the CIMS data repository model and associated interface applications in order to support the collection, integration, and analysis of high-throughput, multi-dimensional data sets through a the use of caBIG developed software components, leveraging the interoperability with those components afforded by the preceding aims. In addition, we intend to make the research products generated by the project available to the broader biomedical research community through a process of open-source distribution of all project-related software components. This final aim is intended to support the rapid development of similar translational research information management platforms in analogous projects and programs. The success of this project will be afforded through the unique combination of: 1) a robust and mature information management system and associated development and management expertise within the CRC; 2) the advanced data management and grid-computing middleware development expertise and products already resident within the applicant organization; and 3) the strong commitment of the CRC investigator community and research staff to the execution of this project. Narrative The proposed project Re-engineering the CLL Research Consortium Integrated Information Management System will increase the ability of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) to conduct translational studies intended to identify and evaluate curative strategies for CLL, the most prevalent form of adult Leukemia in the United States. The CRC is uniquely suited to conduct the types of phenotype bio-marker mapping studies required to develop and validate both novel biological models of CLL (including predictive bio- markers capable of enabling adaptive therapy) and therapeutic approaches to the disease. Therefore, the provision of an improved infrastructure to conduct such studies should have a direct impact of the speed, efficiency, and quality of such activities, thus increase the opportunity to improve the health of patients diagnosed with CLL.

描述（由申请人提供）：摘要/摘要拟议项目重新设计CLL研究联盟综合信息管理系统的目的是通过采用和使用标准基于标准的数据库库平台，Interchange和分析工具和分析工具和分析工具，提高慢性淋巴细胞性白血病（CLL）研究协会（CRL）研究联盟（CRC）的总体翻译研究能力。这种组件的使用最终旨在支持高通量，多维生物医学数据的发现，集成，分析，存储和传播，以支持转化假设发现和测试。将通过针对现有的CRC集成信息管理系统（CIMS）重新工程的目标计划来实现此目标，该计划的目标是：1）数据存储库和基于Web的接口应用程序的迁移到高级，开放式数据库管理系统和企业信息门户网站平台； 2）将开发和使用既可以在CIMS和NCI-EV之间启用语义互操作性以及CAGRID符合CAGRID的数据互换应用程序，该应用将利用该本体学，该应用程序将共同使CIMS与CAGRID和CAGRID和更广泛的Cabig环境促进CIM的整合； 3）CIMS数据存储库模型和关联的接口应用程序的扩展，以支持通过使用Cabig开发的软件组件的高通量，多维数据集的收集，集成和分析，从而利用了与先例目标提供的那些组件相互操作性。此外，我们打算通过将所有与项目相关的软件组件的开源分布进行的过程使项目生成的研究产品可为更广泛的生物医学研究社区提供。这个最终目标旨在支持类似项目和计划中类似的翻译研究信息管理平台的快速发展。该项目的成功将通过：1）CRC内的强大而成熟的信息管理系统以及相关的开发和管理专业知识来实现​​。 2）高级数据管理和网格计算中的中间件开发专业知识和已经居住在申请人组织中的产品； 3）CRC调查员社区和研究人员对执行该项目的坚定承诺。叙述拟议的项目重新研究CLL研究联盟综合信息管理系统将提高慢性淋巴细胞性白血病（CLL）研究联盟（CRC）进行转化研究的能力，旨在识别和评估CLL治疗策略，CLL是美国最普遍的成人白血病。 CRC非常适合进行开发和验证CLL新型生物学模型所需的表型生物标志物映射研究的类型（包括能够实现适应性疗法的预测生物标志物）和对疾病的治疗方法。因此，提供改进的基础设施来进行此类研究应直接影响此类活动的速度，效率和质量，从而增加改善诊断为CLL患者健康的机会。