Re-engineering the CRC Integrated Information Management System

摘要/摘要拟议项目再造CLL研究联盟集成信息管理系统的目标是通过采用和使用开源、基于标准的数据存储库、交换平台和分析工具，提高慢性淋巴细胞白血病（CLL）研究联盟（CRC）的整体转化研究能力。使用这些组件的最终目的是支持发现、整合、分析、存储和传播高通量、多维生物医学数据，以支持翻译假设的发现和测试。这一目标将通过对现有CRC综合信息管理系统（CIMS）进行有针对性的重新设计来实现，该系统的目标是：1)将数据存储库和基于web的接口应用程序迁移到先进的开源数据库管理系统和企业信息门户平台；2)开发和使用本体结构，实现CIMS和NCI-EVS之间的语义互操作性，以及使用该本体的符合caGrid的数据交换应用程序，这些应用程序将共同实现CIMS与caGrid和更广泛的caBIG环境的集成；3)扩展CIMS数据存储库模型和相关接口应用程序，以便通过使用caBIG开发的软件组件来支持高吞吐量、多维数据集的收集、集成和分析，并利用上述目标提供的与这些组件的互操作性。此外，我们打算通过所有项目相关软件组件的开源分发过程，将项目产生的研究产品提供给更广泛的生物医学研究界。这一最终目标旨在支持类似项目和计划中类似转化研究信息管理平台的快速发展。这个项目的成功将通过以下独特的组合来实现：1)一个强大而成熟的信息管理系统，以及中心内部相关的开发和管理专业知识；2)先进的数据管理和网格计算中间件开发专业知识和产品已经在申请组织内；3) CRC研究者群体和研究人员对该项目执行的坚定承诺。拟议的项目重组CLL研究联盟集成信息管理系统将提高慢性淋巴细胞白血病（CLL）研究联盟（CRC）进行转化研究的能力，旨在识别和评估CLL的治疗策略，CLL是美国最常见的成人白血病。CRC非常适合进行表型生物标记物定位研究，这些研究需要开发和验证CLL的新型生物学模型（包括能够实现适应性治疗的预测性生物标记物）和治疗方法。因此，为开展此类研究提供改进的基础设施应直接影响此类活动的速度、效率和质量，从而增加改善慢性淋巴细胞白血病患者健康状况的机会。

DESCRIPTION (provided by applicant): Summary/Abstract The goal of the proposed project Re-engineering the CLL Research Consortium Integrated Information Management System is to increase the overall translational research capacity of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) through the adoption and use of open-source, standards based data repositories, interchange platforms, and analysis tools. The use of such components is ultimately intended to support the discovery, integration, analysis, storage, and dissemination of high-throughput, multi-dimensional biomedical data in support of translational hypothesis discovery and testing. This goal will be achieved through a targeted program of re-engineering of the existing CRC Integrated Information Management System (CIMS) that will have as its aims: 1) the migration of data repositories and web-based interface applications to an advanced, open-source database management system and enterprise information portal platform; 2) the development and use of both an ontology construct that will enable semantic interoperability between CIMS and the NCI-EVS and a caGrid compliant data interchange application that will utilize that ontology, which collectively will enable the integration of CIMS with caGrid and the broader caBIG environment; and 3) the extension of the CIMS data repository model and associated interface applications in order to support the collection, integration, and analysis of high-throughput, multi-dimensional data sets through a the use of caBIG developed software components, leveraging the interoperability with those components afforded by the preceding aims. In addition, we intend to make the research products generated by the project available to the broader biomedical research community through a process of open-source distribution of all project-related software components. This final aim is intended to support the rapid development of similar translational research information management platforms in analogous projects and programs. The success of this project will be afforded through the unique combination of: 1) a robust and mature information management system and associated development and management expertise within the CRC; 2) the advanced data management and grid-computing middleware development expertise and products already resident within the applicant organization; and 3) the strong commitment of the CRC investigator community and research staff to the execution of this project. Narrative The proposed project Re-engineering the CLL Research Consortium Integrated Information Management System will increase the ability of the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) to conduct translational studies intended to identify and evaluate curative strategies for CLL, the most prevalent form of adult Leukemia in the United States. The CRC is uniquely suited to conduct the types of phenotype bio-marker mapping studies required to develop and validate both novel biological models of CLL (including predictive bio- markers capable of enabling adaptive therapy) and therapeutic approaches to the disease. Therefore, the provision of an improved infrastructure to conduct such studies should have a direct impact of the speed, efficiency, and quality of such activities, thus increase the opportunity to improve the health of patients diagnosed with CLL.