Biomedical Informatics

生物医学信息学

• 批准号: 8380671
• 负责人: PHILIP R.O. PAYNE
• 金额: $ 13.14万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8380671
• 关键词: Address; Area; Basic Science; Biostatistics Core; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Comprehensive Cancer Center; Computer software; Data; Data Analyses; Data Set; Data Sources; Database Management Systems; Databases; Development; Ensure; Epigenetic Process; General Population; Genes; Genetic; Health Benefit; Instruction; Internet; Knowledge Discovery; Methods; Ohio; Online Systems; Ontology; Participant; Pharmaceutical Chemistry; Pilot Projects; Program Development; Public Health; Research; Research Personnel; Resource Sharing; Risk; Science; Secure; Services; Structure; Surveys; System; Technology; Therapeutic; Tissues; Universities; Update; Work; biomedical informatics; caGrid; catalyst; clinical application; clinical practice; data exchange; electronic data; interoperability; lenalidomide; leukemia; leukemia tissue bank; member; middleware; news; operation; research study; silvestrol; tool; translational study; web site

The primary objective of the Biomedical Informatics Core (BMIC) is to facilitate the collecfion, management, ntegration, and analysis of a complete spectrum of information types required for the efficient operation of the SPORE'S projects, pilots, and other cores. Examples of these informafion types include stmctured and semi-structured data sets resulting from: 1) experimental studies; 2) biostatistical analyses; 3) fissue core and administrative operations; 4) shared resource services; and 5) the asynchronous collaborafion of SPORE participants. We will achieve this objecfive using a combinafion biomedical informafics best practices and advanced technologies already in use or under development within The Ohio State University (OSU) Department of Biomedical Informafics (OSU-BMI) and The Ohio State University Comprehensive Cancer Center (OSU-CCC). Such technologies include: 1) the service-oriented caGrid middleware for electronic data interchange between heterogeneous biomedical data sources and analytical services; 2) advanced database management systems optimized for the storage and query of rapidly evolving biomedical data sets; 3) centralized ontology services and ontology-anchored knowledge discovery/management tools; 4) mulfiple task-specific web-portal applicafions that support the discovery, integration, and analysis of large scale, multi-dimensional data sets; and 5) web-based collaborative team-science tools. We envision the BMIC as being the central information coordination "hub" of the SPORE. In order to achieve these objectives, the specific aims of the biomedical informafics core are to: 1) develop and support extensible database management systems for use by SPORE participants; 2) enable electronic data interchange between SPORE-related data sources; 3) support task-specific web portal applications that allow end users to discover, integrate, and analyze SPORE-related data sources; 4) support the execution of SPORE-related clinical trials through the facilitation of access to the OSU-CCC's enterprise-grade clinical trials management system; and 5) implement and support a collaborative web portal intended to serve as a medium for both team-science and public disseminafion acfivities. RELEVANCE (See instructions): The Biomedical Informafics Core's (BMIC) activifies as part of this SPORE will cover a wide spectrum, from the facilitafion of high-throughput data analyses to the provision of tools to enable the collaboration of temporally or geographically distributed investigators. As such, the BMIC will serve as a catalyst for the rapid and efficient conduct of translational studies, with the effect of accelerating the translafion and dissemination of basic science discoveries into clinical practice and ultimately public health benefits.

生物医学信息学核心（BMIC）的主要目的是促进集合，管理， ntegration，以及对有效操作所需的完整信息类型的分析 孢子的项目，飞行员和其他核心。这些信息类型类型的示例包括STMCTURED和 半结构化数据集产生的：1）实验研究； 2）生物统计分析； 3）Fissue Core 和行政行动； 4）共享资源服务； 5）异步合作 孢子参与者。我们将使用Combinafion Biomedical Informafics实现这一观点 俄亥俄州立大学已经使用或正在开发的实践和高级技术 （OSU）生物医学信息法（OSU-BMI）和俄亥俄州立大学综合 癌症中心（OSU-CCC）。这样的技术包括：1）面向服务的CAGRID中间件 异质生物医学数据源和分析服务之间的电子数据互换； 2） 为快速发展的生物医学的存储和查询而优化了高级数据库管理系统 数据集； 3）集中的本体学服务和本体论的知识发现/管理工具； 4）支持大型发现，集成和分析的Mulfiple特定于特定任务的Web-Portal应用程序 比例，多维数据集； 5）基于Web的协作团队科学工具。我们设想 BMIC是孢子的中央信息协调“中心”。为了实现这些 目标，生物医学信息核心的具体目的是：1）开发和支持可扩展的 孢子参与者使用的数据库管理系统； 2）启用电子数据互换 与孢子相关的数据源之间； 3）支持特定于任务的Web门户网站应用程序，该应用程序允许最终用户 发现，整合和分析与孢子相关的数据源； 4）支持执行孢子相关的 通过促进访问OSU-CCC的企业级临床试验管理的临床试验 系统; 5）实施和支持协作网站，旨在作为两者的媒介 团队科学和公共侵犯。 相关性（请参阅说明）： 作为该孢子的一部分，生物医学Informafics Core（BMIC）将涵盖广泛的范围 高通量数据分析的协助提供了提供工具，以实现合作 时间或地理分布的研究人员。因此，BMIC将作为催化剂 快速有效地进行翻译研究，并加速翻译和 将基础科学发现传播到临床实践中，并最终使公共卫生益处。