Lipidomics Shared Resource

霍林斯癌症中心(HCC)脂肪组学分享 南卡罗来纳医科大学独有的。这是 并促进对生物活性脂类作用的研究 代谢物，包括二酰甘油、磷脂酰肌醇 鞘氨醇、神经酰胺-1-磷酸和鞘氨醇-1 调节和调节各种细胞反应，包括 炎症、细胞迁移和细胞衰老。多么 很有挑战性。它们的较差的水溶性使它们 准确的分析需要复杂的设备，例如 需要作为量化和功能的标准 共享资源拥有一支出色的团队， 高灵敏度、高精度检测技术的发展 以及生物活性脂类和新型芳香酸的合成 提供最先进的设施和先进的 否则就会贵得令人望而却步。 脂肪组学共享研究的具体目标 ？提供合成类脂、其类似物和抑制剂 鞘脂类 ？提供脂类的定性和定量分析 ？协助肝细胞癌调查人员设计和制作 生物活性脂类及其代谢、分析和功能 ？改进和开发脂质分析的新技术 生物活性脂类的作用与新的潜在安非他命 正常细胞和转化细胞的组成及O 来分析他们的新陈代谢

The Hollings Cancer Center (HCC) Lipidomics Shared unique to the Medical University of South Carolina. Th and promote research into the role of bioactive lipids a metabolites, including diacylglycerol, phosphatidylinosi sphingosine, ceramide-1 -phosphate and sphingosine-1 that mediate and regulate various cell responses, inclu inflammation, cell migration and cell senescence. How challenging. Their poor water solubility makes these m accurate analysis requires sophisticated equipment, ar needed as standards for quantification and for function Shared Resource is staffed by an exceptional group of development of sensitive and accurate techniques for t well as the synthesis of bioactive lipids and novel anak provision of state-of-the-art facilities and sophisticated otherwise be prohibitively expensive. The specific objectives of the Lipidomics Shared Resoi ¿ Provide synthetic lipids, their analogs, and inhibitor sphingolipids ¿ Provide qualitative and quantitative analysis of lipid ¿ Assist HCC investigators in the design and conduc bioactive lipids, their metabolism, analysis and func ¿ Improve and develop new techniques for lipid anah the role of bioactive lipids and new potential antica composition of normal and transformed cells and o to analysis of their metabolism