Lipidomics Shared Resource

Hollings癌症中心（HCC）脂质组学分享 是南卡罗来纳州医科大学独有的日 并促进对生物活性脂质的作用的研究， 代谢物，包括甘油二酯、磷脂酰肌醇 鞘氨醇、神经酰胺-1-磷酸和鞘氨醇-1 介导和调节各种细胞反应，包括 炎症、细胞迁移和细胞衰老。如何 挑战性它们的水溶性差，使这些物质 准确的分析需要精密的设备， 作为量化和功能的标准 共享资源由一个特殊的小组组成， 发展灵敏准确的检测技术， 以及生物活性脂质和新型anak的合成 提供最先进的设施和先进的 否则会非常昂贵。 Lipidomics Shared Resoi的具体目标 提供合成脂质，其类似物和抑制剂 鞘脂 提供脂质的定性和定量分析 协助HCC调查员进行设计和调试 生物活性脂类及其代谢、分析和功能 <$改善和开发新技术的脂质分析 生物活性脂质作用及新的潜在抗癌剂 正常细胞和转化细胞的组成， 分析他们的新陈代谢

The Hollings Cancer Center (HCC) Lipidomics Shared unique to the Medical University of South Carolina. Th and promote research into the role of bioactive lipids a metabolites, including diacylglycerol, phosphatidylinosi sphingosine, ceramide-1 -phosphate and sphingosine-1 that mediate and regulate various cell responses, inclu inflammation, cell migration and cell senescence. How challenging. Their poor water solubility makes these m accurate analysis requires sophisticated equipment, ar needed as standards for quantification and for function Shared Resource is staffed by an exceptional group of development of sensitive and accurate techniques for t well as the synthesis of bioactive lipids and novel anak provision of state-of-the-art facilities and sophisticated otherwise be prohibitively expensive. The specific objectives of the Lipidomics Shared Resoi ¿ Provide synthetic lipids, their analogs, and inhibitor sphingolipids ¿ Provide qualitative and quantitative analysis of lipid ¿ Assist HCC investigators in the design and conduc bioactive lipids, their metabolism, analysis and func ¿ Improve and develop new techniques for lipid anah the role of bioactive lipids and new potential antica composition of normal and transformed cells and o to analysis of their metabolism