PET STUDIES OF COCAINE ABUSE: EFFECTS OF EXPECTATION

可卡因滥用的宠物研究：期望的影响

• 批准号: 7950803
• 负责人: GENE-JACK WANG
• 金额: $ 2.12万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950803
• 关键词: Blood Circulation; Brain; Chemicals; Clinical Research; Cocaine; Cocaine Abuse; Computer Retrieval of Information on Scientific Projects Database; Feeling; Funding; Grant; Institution; Magnetic Resonance Imaging; Measures; Methylphenidate; Moods; Placebo Effect; Placebos; Positron-Emission Tomography; Radioactive; Reaction; Reporting; Research; Research Personnel; Resources; Source; United States National Institutes of Health; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to look at reactions in the brain when a subject is expecting to receive a substance that causes a reaction in the brain similar to cocaine (methylphenidate) as opposed to the brain reaction when they actually receive methylphenidate. This will be done using Magnetic Resonance Imaging (MRI) to track a radiotracer (a radioactive chemical that is injected into the bloodstream) after the methylphenidate or a placebo is injected. Subjective measures will also be measured by asking cocaine abusers to report current feelings and mood throughout the study, and compare these subjective reports with the PET scans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是观察受试者预期接受某种物质时大脑的反应，这种物质会在大脑中引起类似于可卡因（哌醋甲酯）的反应，而不是当他们实际接受哌甲酯时的大脑反应。 注射哌醋甲酯或安慰剂后，将使用磁共振成像 (MRI) 来追踪放射性示踪剂（一种注入血液中的放射性化学物质）。 还将通过要求可卡因滥用者报告整个研究过程中当前的感受和情绪，并将这些主观报告与 PET 扫描进行比较来测量主观测量。