CLINICAL TRIAL: BRAIN RESPONSE TO VISCERAL SENSATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在美国和世界范围内，肥胖症的发病率已经达到流行病的比例，并继续上升。与肥胖相关的发病率和死亡率的增加迫切需要了解导致这种流行病的过程。这项研究的好处是了解了肥胖受试者大脑功能的变化，以及当胃扩张时这些变化对他们进食行为的影响。这些结果将有助于我们更好地理解植入式胃刺激（IGS）的机制，因为其部分机制是产生电信号以诱导器官末端（胃底）的扩张，从而导致食物摄入量减少和体重减轻。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of obesity in the USA and in the world has reached epidemic proportions and continue to rise. The increased morbidity and mortality associated with obesity places a sense of urgency to understand the processes that have contributed to this epidemic. The benefits from this study are knowledge of the changes in brain function in obese subjects and the consequences of these changes on their feeding behaviors when the stomach is distended. The results will help us to better understand the mechanisms of implantable gastric stimulation (IGS), since part of its mechanism is generating electric signals to induce the expansion of the end of the organ (fundus) which leads to decreased food intake and reduced body weight.