CLINICAL TRIAL: BRAIN DOPAMINE, REWARD AND MOTIVATION IN OBESE SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多巴胺是一种神经递质，通过调节食物的有益特性以及食物消费的动机和欲望来调节食物的消费。一些研究表明，病态肥胖受试者的多巴胺受体可获得性与他们的BMI成正比，这可能会使病理性进食成为一种补偿这些回路激活减少的手段。 然而，暴饮暴食的肥胖受试者和不暴饮者之间的大脑多巴胺活性似乎存在差异。 这项研究的目的是通过正电子发射断层扫描观察对食物刺激的反应来探索这种差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dopamine is one of the neurotransmitters involved in regulating food consumption through modulation of the rewarding properties of food and the motivation and desire for food consumption. Some studies have shown that morbidly obese subjects have reduced Dopamine receptor availability proportional to their BMI, which may perpetuate pathologic eating as a means to compensate for decreased activation of these circuits. It appears, however, that their is a difference in brain dopamine activity between obese subjects who are binge eaters and those who aren't. It is the purpose of this study to explore the difference by observing responses to food stimulation through Positron Emission Tomography.