CLINICAL TRIAL: BRAIN DOPAMINE, REWARD AND MOTIVATION IN OBESE SUBJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 多巴胺是一种神经递质，通过调节食物的奖励特性以及食物消费的动机和欲望来参与调节食物消费。一些研究表明，病态肥胖受试者的多巴胺受体可用性与他们的BMI成正比，这可能使病理性进食永久化，作为补偿这些回路激活减少的手段。 然而，肥胖的暴饮暴食者和非暴饮暴食者的大脑多巴胺活动似乎存在差异。 本研究的目的是通过正电子发射断层扫描观察食物刺激的反应来探索差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dopamine is one of the neurotransmitters involved in regulating food consumption through modulation of the rewarding properties of food and the motivation and desire for food consumption. Some studies have shown that morbidly obese subjects have reduced Dopamine receptor availability proportional to their BMI, which may perpetuate pathologic eating as a means to compensate for decreased activation of these circuits. It appears, however, that their is a difference in brain dopamine activity between obese subjects who are binge eaters and those who aren't. It is the purpose of this study to explore the difference by observing responses to food stimulation through Positron Emission Tomography.