CLINICAL TRIAL: IMAGING OF BRAIN METABOLIC RESPONSES TO FOOD PRESENTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对于这项先导性研究，我们首先想评估IRB 326(第III.B节)中使用的食物呈现对正常受试者葡萄糖代谢的影响(研究I)。受试者将接受3次18F-氟代脱氧葡萄糖(FDG)PET扫描，将在三个不同的日期(A、B或C)进行，以评估行为干预(视觉、嗅觉和知觉呈现/接触食物)、中性干预(视觉、嗅觉和知觉暴露在图片、玩具、服装或问题等不会导致强烈情绪或反应的事物)和基线(不干预)条件的效果。在行为干预或中性干预当天，干预将在FDG注射前15分钟开始，总共持续45分钟。当这一范式能够评估对照组受试者的代谢变化时，我们将比较肥胖受试者的脑代谢变化(研究2)。这一信息是至关重要的，因为如果我们不能使用这一范式观察到显著的大脑葡萄糖代谢变化，我们将无法进行第二项研究，我们将根据我们获得的初步数据修改这项研究。我们会将任何建议的更改重新提交内部审查委员会审批。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For this pilot study we first want to assess the effect of food presentation, which has been used in IRB 326 (Section III.B), on glucose metabolism in normal subjects (Study I). Subjects will have 3 PET scans with 18F-fluorodeoxyglucose (FDG), which will be given on three different days (A, B or C) to assess the effects of behavioral intervention (visual, olfactory and perceptual presentation/exposure to food), neutral intervention (visual, olfactory and perceptual exposure to things such as pictures, toys, clothing items or questions that do not result in a strong emotional feeling or response) and baseline (no intervention) conditions. On the day of the behavioral or neutral intervention, the intervention will be started 15 minutes prior to FDG injection and will be continued for a total of 45 minutes. When this paradigm is feasible to assess the metabolic changes in control subjects, we will then compare the brain metabolic changes with obese subjects (Study #2). This information is essential because if we can't observe significant brain glucose metabolic changes using this paradigm we won't be able to do Study #2 and we will revise this study according to the preliminary data we have obtained. We will resubmit any proposed changes to the IRB for approval.