EFFECT OF INTRAVENOUS ASCORBIC ACID ON OXIDATIVE STRESS AND CYTOKING ACTIVATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在研究维生素C补充剂在贫血患者中的使用。这项研究的目的是确定维生素C在接受静脉铁治疗的终末期肾病患者中是否安全。 慢性肾脏疾病的氧化应激[可损害身体的氧气]和炎症可能会增加心脏问题和死亡的风险。这可能是由于糖尿病等健康问题，也可能是透析膜和静脉补铁造成的。铁引起的氧化应激和炎症会导致你的促红细胞生成素治疗效果不佳。很少有治疗方法可以帮助减少对促红细胞生成素的反应。最近的研究发现，静脉注射维生素C可能会改善身体对促红细胞生成素的反应。维生素C疗法的一个问题是它会增加体内的游离铁。这种效应可能会增加氧化应激的几率，但这种效应仍不清楚。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is studying the use of vitamin C supplementation in patients with anemia. The purpose of this study is to determine if vitamin C is safe in patients with end stage renal disease who are receiving IV iron. Oxidative stress [oxygen that can harm the body] and inflammation in chronic kidney disease [CKD] may increase the risk of having heart problems and death. This can be from health problems like diabetes mellitus [DM] or from dialysis membranes and IV iron supplementation. Oxidative stress and inflammation from iron can cause your EPO therapy not to work as well. Very few treatments exist to help out a decreased response to EPO. Recent studies have found that taking IV vitamin C may improve the body's response to EPO. One problem with vitamin C therapy is that it can increase free iron within the body. This effect may increase the chance of oxidative stress, but this effect is still unknown.