CYTOKINE ACTIVATION AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS RECEIVING IV N

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该提案将检验中心假设：血液透析患者静脉补铁相关的非转铁蛋白结合铁（NTBI）产生显著的细胞因子活化、氧化应激和DNA损伤。 研究目的： 1.探讨静脉补铁诱导的细胞因子活化与炎症反应及氧化应激的关系。 2.确定IV铁引起的氧化应激是否导致多形核细胞（PBMC）的DNA损伤。 3.比较相对不稳定（蔗糖铁）和稳定（右旋糖酐铁）铁制剂产生的细胞因子激活、炎症和氧化应激以及DNA损伤的程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal will examine the central hypothesis that: Non-transferrin bound iron (NTBI) associated with intravenous iron supplementation in hemodialysis patients produces significant cytokine activation, oxidative stress and DNA damage. Study Aims: 1. To study the relationship between cytokine activation, inflammation and oxidative stress induced by intravenous iron administration. 2. To determine if oxidative stress from IV iron causes DNA damage in polymorphnuclear cells (PBMC's). 3. To compare the magnitude of cytokine activation, inflammation and oxidative stress and DNA damage produced by relative labile (iron surcrose) and stable (iron dextran) iron preparations.