STU1P FUNCTION IN YEAST MITOSIS THROUGH ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS

通过分析蛋白质-蛋白质相互作用了解酵母有丝分裂中的 STU1P 功能

• 批准号: 7957853
• 负责人: DAVID G DRUBIN
• 金额: $ 0.7万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957853
• 关键词: Biology; Computer Retrieval of Information on Scientific Projects Database; Funding; Fungal Genome; Grant; Institution; Maintenance; Mitosis; Mitotic spindle; Proteins; Research; Research Personnel; Resources; Role; Saccharomyces cerevisiae Proteins; Source; United States National Institutes of Health; Yeasts; interest; member; protein protein interaction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Saccharomyces cerevisiae protein Stu1p has an essential role in mitotic spindle function. It is necessary for mitotic spindle formation and maintenance. Stu1p is part of a network of proteins localized at the mitotic spindle midzone. We are attempting to understand the protein-protein interactions within this spindle midzone network, to better understand the establishment and maintenance of the mitotic spindle. Since Stu1p is an essential member of this network, we are interested in understanding whether it interacts with other midzone proteins, and whether these interactions are necessary for Stu1p function.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 酿酒酵母蛋白Stu 1 p在有丝分裂纺锤体功能中具有重要作用。它是有丝分裂纺锤体形成和维持所必需的。Stu 1 p是位于有丝分裂纺锤体中区的蛋白质网络的一部分。我们正试图了解这个纺锤体中间区网络中的蛋白质-蛋白质相互作用，以更好地了解有丝分裂纺锤体的建立和维持。由于Stu 1 p是这个网络的重要成员，我们有兴趣了解它是否与其他中间区蛋白相互作用，以及这些相互作用是否是Stu 1 p功能所必需的。