Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo

使用单细胞基因组学解决体内 CD4 T 细胞的功能多样化

• 批准号: nhmrc : 1126399
• 负责人: A/Pr Ashraful Haque
• 金额: $ 71.57万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-single-cell-cells-vivo/947791
• 关键词: Using; single; cell; genomics; resolve

During immune responses, individual CD4+ T cells multiply and produce hundreds of descendants, with close relatives within a family often developing very different skills. How such differences emerge from one ancestor remains unclear. We use new methods to look at individual CD4+ T cells in unprecedented detail, allowing us to see how close relatives begin to grow apart. Using this, we hope to find novel ways of educating CD4+ T cells to prevent infectious and immune-mediated diseases.

在免疫反应过程中，单个CD4+ T细胞繁殖并产生数百个后代，而家庭中的近亲往往会发展出截然不同的技能。这种差异是如何从一个祖先中产生的尚不清楚。我们使用新方法以前所未有的细节观察单个CD4+ T细胞，使我们能够看到近亲是如何开始分开生长的。利用这一点，我们希望找到新的方法来教育CD4+ T细胞来预防传染性和免疫介导的疾病。