Cytokine responses within the GI tract dictate T cell fate and transplant outcome

胃肠道内的细胞因子反应决定 T 细胞命运和移植结果

• 批准号: nhmrc : 1146859
• 负责人: A/Pr Ashraful Haque
• 金额: $ 98.66万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokine-responses-gi-transplant-outcome/1320748
• 关键词: Cytokine; responses; within; GI; tract

Over 10,000 persons per year in Australia are diagnosed with a blood cancer, accounting for 10% of cancer deaths. Stem cell transplantation remains curative therapy for these diseases but is limited by a process known as graft-versus-host disease (GVHD), responsible for mortality in up to 50% of patients. This project will focus on immune responses within the colon as the critical event initiating lethal GVHD, defining new treatments that will be translated to improve transplant outcomes.

澳大利亚每年有超过 10,000 人被诊断患有血癌，占癌症死亡人数的 10%。干细胞移植仍然是这些疾病的治疗方法，但受到移植物抗宿主病 (GVHD) 过程的限制，该疾病导致高达 50% 的患者死亡。该项目将重点关注结肠内的免疫反应，作为引发致命 GVHD 的关键事件，确定新的治疗方法，以改善移植结果。