Cytokine responses within the GI tract dictate T cell fate and transplant outcome

胃肠道内的细胞因子反应决定 T 细胞命运和移植结果

• 批准号: nhmrc : GNT1146859
• 负责人: A/Pr Ashraful Haque
• 金额: $ 145.92万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokine-responses-gi-transplant-outcome/1348790
• 关键词: Cytokine; responses; within; GI; tract

Over 10,000 persons per year in Australia are diagnosed with a blood cancer, accounting for 10% of cancer deaths. Stem cell transplantation remains curative therapy for these diseases but is limited by a process known as graft-versus-host disease (GVHD), responsible for mortality in up to 50% of patients. This project will focus on immune responses within the colon as the critical event initiating lethal GVHD, defining new treatments that will be translated to improve transplant outcomes.

在澳大利亚，每年有1万多人被诊断出患有血癌，占癌症死亡人数的10%。干细胞移植仍然是这些疾病的根治疗法，但受到一种称为移植物抗宿主病(GVHD)的过程的限制，该过程导致高达50%的患者死亡。该项目将重点研究结肠内的免疫反应，作为启动致命性GVHD的关键事件，定义将被转化为改善移植结果的新治疗方法。