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Cytokine responses within the GI tract dictate T cell fate and transplant outcome

Cytokine responses within the GI tract dictate T cell fate and transplant outcome
胃肠道内的细胞因子反应决定 T 细胞命运和移植结果
批准号：
nhmrc : GNT1146859
负责人：
A/Pr Ashraful Haque
金额：
$145.92万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 --
来源：
https://researchdata.edu.au/cytokine-responses-gi-transplant-outcome/1348790
关键词：
CytokineresponseswithinGItract

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中文摘要
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英文摘要
Over 10,000 persons per year in Australia are diagnosed with a blood cancer, accounting for 10% of cancer deaths. Stem cell transplantation remains curative therapy for these diseases but is limited by a process known as graft-versus-host disease (GVHD), responsible for mortality in up to 50% of patients. This project will focus on immune responses within the colon as the critical event initiating lethal GVHD, defining new treatments that will be translated to improve transplant outcomes.
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Cytokine responses within the GI tract dictate T cell fate and transplant outcome
Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo
Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo
  • 批准号：
    nhmrc : GNT1126399
  • 项目类别：
    Project Grants
  • 资助金额：
    $104.81万
  • 财政年份：
    2017
  • 负责人：
    A/Pr Ashraful Haque
  • 依托单位：
Defining immune regulation and T cell responses during chronic infectious disease.
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