FMRI ABILITY TO MAP COLUMNAR STRUCTURES IN HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的4年里，我们挑战了BOLD功能磁共振成像在人类亚毫米结构(即皮质柱)和动物模型中的板层特异性的限制。确定了高场SE BOLD技术更适合于柱状构造的填图。我们采用高场SE大胆对比度的策略使我们能够探索，除了ODC之外，人脑中以前未被映射的定向柱。在这里，我们将为人类高分辨率fMRI采集开发更大容量覆盖的新功能，以及继续应用和开发高分辨率动物fMRI模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past 4 years, we have challenged the limits of BOLD fMRI to the level of sub-millimeter structures (i.e. cortical columns) in humans and laminar specificity in the animal model. We have established that SE BOLD technique at high fields is more suitable for mapping columnar structures. Our strategy of employing high-field SE BOLD contrast has allowed us to explore, in addition to ODCs, orientation columns in the human brain, which were previously unmapped. Here, we will develop new capabilities for larger volume coverage for high-resolution fMRI acquisitions in humans as well as continued application and development of a high resolution animal fMRI model.