FMRI ABILITY TO MAP COLUMNAR STRUCTURES IN HUMANS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在过去的4年中，我们已经挑战了BOLD功能磁共振成像的限制，在人类的亚毫米结构（即皮质柱）的水平和动物模型中的层状特异性。我们已经确定，SE BOLD技术在高场更适合映射柱状结构。我们采用高场SE BOLD对比度的策略使我们能够探索，除了ODC，在人脑中的方向列，这是以前未映射。在这里，我们将开发新的能力，为更大的体积覆盖率的高分辨率fMRI采集在人类以及继续应用和发展的高分辨率动物fMRI模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past 4 years, we have challenged the limits of BOLD fMRI to the level of sub-millimeter structures (i.e. cortical columns) in humans and laminar specificity in the animal model. We have established that SE BOLD technique at high fields is more suitable for mapping columnar structures. Our strategy of employing high-field SE BOLD contrast has allowed us to explore, in addition to ODCs, orientation columns in the human brain, which were previously unmapped. Here, we will develop new capabilities for larger volume coverage for high-resolution fMRI acquisitions in humans as well as continued application and development of a high resolution animal fMRI model.