SPATIAL SPECIFICITY OF HIGH-RESOLUTION, SPIN-ECHO BOLD AND CBF FMRI AT 7T

7T 下高分辨率、Spin-Echo BOLD 和 CBF FMRI 的空间特异性

• 批准号: 7601637
• 负责人: ESSA YACOUB
• 金额: $ 2.36万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601637
• 关键词: Address; Animals; Blood; Communication; Computer Retrieval of Information on Scientific Projects Database; Core-Binding Factor; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Institution; Letters; Maps; Publishing; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Specificity; United States National Institutes of Health; Voice; Weight; base; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In his letter, Dr. Duyn expresses concerns regarding the spatial specificity of our spin-echo (SE) BOLD and CBFbased functional mapping signals (1) because of inherent T*2 weighting in EPI images, blood contributions to SE BOLD, and BOLD effects in CBF-based fMRI. Detailed verification or discussion of these points was beyond the scope of our article (1), since it was submitted as a Note (although published as a Communication) addressing technical issues of high-resolution SE BOLD and CBF fMRI in humans at 4 and 7 T where EPI confronts major diffi- culties. Consequently, our remarks on the spatial specificity of fMRI were based on animal studies at high fields (2,3). However, the issues voiced by Dr. Duyn were indeed mentioned in the original article (1), and were fully dealt with in two articles published shortly afterwards (4,5). Our responses to Dr. Duyn?s three points are summarized below.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Duyn博士在信中对以下问题表示关切： 我们基于自旋回波（SE）BOLD和CBF的空间特异性 功能映射信号（1），因为固有的 EPI图像中的T*2加权，血液对SE的贡献 BOLD和基于CBF的fMRI中的BOLD效应。详细 对这些问题的验证或讨论超出了 我们的文章（1）的范围，因为它是作为一个说明提交的 （虽然作为来文发表） 高分辨率SE BOLD和CBF fMRI的技术问题 在人类中，在4和7 T时，EPI面临着主要的困难， 邪教因此，我们对空间特异性的评论 的功能磁共振成像是基于动物研究在高场 （2，3）。然而，杜恩博士提出的问题确实是 原第（1）条中提到的，并得到充分处理 在两篇文章发表后不久（4，5）。我们 对杜恩医生的回应现将这三点归纳如下。