SPATIAL SPECIFICITY OF HIGH-RESOLUTION, SPIN-ECHO BOLD AND CBF FMRI AT 7T

7T 下高分辨率、Spin-Echo BOLD 和 CBF FMRI 的空间特异性

• 批准号: 7721358
• 负责人: ESSA YACOUB
• 金额: $ 3.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721358
• 关键词: Address; Animals; Blood; Communication; Computer Retrieval of Information on Scientific Projects Database; Core-Binding Factor; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Institution; Letters; Maps; Publishing; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Specificity; United States National Institutes of Health; Voice; Weight; base; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In his letter, Dr. Duyn expresses concerns regarding the spatial specificity of our spin-echo (SE) BOLD and CBFbased functional mapping signals (1) because of inherent T*2 weighting in EPI images, blood contributions to SE BOLD, and BOLD effects in CBF-based fMRI. Detailed verification or discussion of these points was beyond the scope of our article (1), since it was submitted as a Note (although published as a Communication) addressing technical issues of high-resolution SE BOLD and CBF fMRI in humans at 4 and 7 T where EPI confronts major diffi- culties. Consequently, our remarks on the spatial specificity of fMRI were based on animal studies at high fields (2,3). However, the issues voiced by Dr. Duyn were indeed mentioned in the original article (1), and were fully dealt with in two articles published shortly afterwards (4,5). Our responses to Dr. Duyn?s three points are summarized below.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Duyn 博士在信中表达了对 我们的自旋回波 (SE) BOLD 和 CBF 的空间特异性 功能映射信号 (1) 由于固有的 EPI 图像中的 T*2 加权、血液对 SE 的贡献 基于 CBF 的 fMRI 中的 BOLD 和 BOLD 效果。详细的 对这些要点的验证或讨论超出了 我们文章 (1) 的范围，因为它是作为注释提交的 （尽管作为通讯发布）寻址 高分辨率SE BOLD和CBF fMRI的技术问题 在 4 和 7 T 的人类中，EPI 面临着主要的困难 邪教。因此，我们对空间特殊性的评论 功能磁共振成像的研究基于高场动物研究 (2,3)。然而，Duyn博士提出的问题确实是 原文章（1）中提到过，并已全面处理 随后不久发表了两篇文章 (4,5)。我们的 对 Duyn 博士三点的回应总结如下。