HIGH FIELD MRI: LIMITATIONS AND SOLUTIONS

高场 MRI：局限性和解决方案

• 批准号: 7954977
• 负责人: Christopher M Collins
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954977
• 关键词: Address; Animals; Biomedical Engineering; Cells; Computer Retrieval of Information on Scientific Projects Database; Computer software; Educational workshop; Engineering; Evaluation; Frequencies; Functional Magnetic Resonance Imaging; Funding; Grant; Head; Human; Institution; Laboratories; Laboratory Research; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Methodology; Microscopy; Minnesota; Modeling; National Center for Research Resources; Noise; Predisposition; Radio; Research; Research Personnel; Resources; Signal Transduction; Solutions; Source; Spectrum Analysis; Speed; Subcellular Anatomy; Techniques; United States National Institutes of Health; Universities; magnetic field; patient safety; regional difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. he objective of this research is to understand and develop engineering solutions to the difficulties presented to magnetic resonance imaging (MRI) at high magnetic field strength. A recent workshop at the University of Minnesota (1999) on high field MRI recently identified magnetic susceptibility induced signal loss, radio frequency magnetic field distortion, and signal-to-noise as the three most pressing issues facing high field implementation. Our partnership will directly address two of these important issues. Specific Aim 1: Develop and validate methodology to analyze, quantify, and ultimately elimiate static magnetic field distortion produced in high field MR images by regional differences in magnetic susceptibility. These solutions will be used to develop distortion-free correction techniques for high-speed functional MRI and distortion-free MRI of human, animal, and cellular anatomy. Specific Aim 2: Develop and validate models and methodology to analyze, and quantify radio frequency (rf) magnetic field distortion occurring in the human head and body. These solutions will be used to evaluate patient safety from absorbed rf energy and to evaluate distortion and limitations of rf field homogeneity and its potential correction. In the spirit of the Bioengineering Research Partnership this proposal will draw expertise and partnership from the Center for Magnetic Resonance Research at the University of Minnesota (a premiere 7.0 Tesla whole body MRI National Research Resource Center), REMCOM (a magnetiac field modeling software company), and the National High FIeld Magnet Laboratory (a National Research Laboratory incorporating 14 Tesla MRI microscopy). The results of these studies will aid a wide array of researchers in high speed distortion-free functional MRI, aanatomical studies at both low and high field strengths, MR microscopy in animals and intact cells, evaluation of patient safety, and in many cases reclaiming techniques which have proven problematic at high field strengths.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是了解和开发工程解决方案，以解决高磁场强度下磁共振成像 (MRI) 遇到的困难。 明尼苏达大学最近举办的高场 MRI 研讨会（1999 年）最近确定了磁化率引起的信号丢失、射频磁场失真和信噪比是高场实施面临的三个最紧迫的问题。 我们的合作伙伴关系将直接解决其中两个重要问题。 具体目标 1：开发和验证方法来分析、量化并最终消除因磁化率区域差异而在高场 MR 图像中产生的静态磁场失真。 这些解决方案将用于开发用于高速功能 MRI 和人体、动物和细胞解剖学的无失真 MRI 的无失真校正技术。 具体目标 2：开发并验证模型和方法来分析和量化人体头部和身体中发生的射频 (rf) 磁场失真。 这些解决方案将用于评估患者吸收射频能量的安全性，并评估射频场均匀性的失真和限制及其潜在校正。 本着生物工程研究合作伙伴关系的精神，该提案将吸收明尼苏达大学磁共振研究中心（首屈一指的 7.0 特斯拉全身 MRI 国家研究资源中心）、REMCOM（磁场建模软件公司）和国家高场磁体实验室（包含 14 特斯拉 MRI 显微镜的国家研究实验室）的专业知识和合作伙伴关系。 这些研究的结果将帮助众多研究人员进行高速无失真功能性 MRI、低场强和高场强下的解剖研究、动物和完整细胞的 MR 显微镜检查、患者安全评估，以及在许多情况下回收在高场强下已被证明存在问题的技术。