RF Technology Innovation for Advancing High Field MR.

推动高场 MR 发展的射频技术创新。

• 批准号: 8433352
• 负责人: Christopher M Collins
• 金额: $ 62.2万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433352
• 关键词: Address; Algorithms; Animals; Behavior; Body Image; Breast; Calibration; Clinical; Computer Analysis; Computer software; Deposition; Detection; Development; Diagnosis; Effectiveness; Error Sources; Frequencies; Goals; Head; Heating; Human; Image; In Situ; Investigation; Lead; Maps; Measurement; Measures; Methodology; Methods; Metric; Modeling; Monitor; Pancreas; Pattern; Performance; Physiologic pulse; Positioning Attribute; Process; Prostate; RF coil; Radio; Research; Resolution; Safety; Scanning; Signal Transduction; Solutions; Speed; Structure; System; Technology; Test Result; Tissues; Translating; Variant; advanced disease; base; clinical practice; design; disease diagnosis; experience; image reconstruction; improved; in vivo; innovation; insight; magnetic field; novel strategies; operation; prototype; public health relevance; research study; simulation; tool; transmission process; trend

DESCRIPTION (provided by applicant): An important trend in MR in recent years has been the move towards higher magnetic field (B0) strengths, which promises to advance disease understanding and diagnosis with enhancements in detection sensitivity, metabolite resolution, imaging speed, and tissue contrast. However there are technical challenges that severely hamper the practice of human high field MR, including a major one that accompanies the creation of MR signal using radio frequency EM fields - B1 and concomitant E fields. As B0 strength increases, the degradation in B1 homogeneity due to increased wave behavior often causes severe image quality issues. Meanwhile E-induced RF heating of the subject body (SAR) poses increasingly inhibiting constraints on the application of high-performance MR sequences. With a great capacity for alleviating the limitations imposed by B1 inhomogeneity and SAR exacerbation, parallel RF transmit is emerging as a key enabling technology for high field MR. This project aims at significantly improving human high field MR capability and safety by creating innovative solutions to spin excitation, RF apparatus, and RF energy deposition in subjects. This will be accomplished with specific efforts on a) developing a much needed non-invasive method for measuring, predicting, and proactively managing SAR, b) leveraging the method in optimizing parallel excitation pulses and in breaking new ground of 7T MR applications, and c) transforming RF hardware and pulse designs to considerably boost high field MR system performance. The successful completion of this project will lead to quantitative / predictive methods that enable the fulfillment of the full potential of in vivo imaging at high field, high impact body imaging applications, and innovative RF methods that promise to bring signal creation and detection performance to a new level.

描述（由申请人提供）：近年来MR的一个重要趋势是向更高的磁场（B 0）强度发展，这有望通过增强检测灵敏度、代谢物分辨率、成像速度和组织对比度来促进疾病理解和诊断。然而，存在严重阻碍人类高场MR实践的技术挑战，包括伴随使用射频EM场- B1和伴随的E场产生MR信号的主要挑战。随着B 0强度的增加，由于波行为的增加而导致的B1均匀性的退化通常会导致严重的图像质量问题。同时，受试者身体（SAR）的E感应RF加热对高性能MR序列的应用造成越来越多的抑制性限制。 并行射频发射能够极大地缓解B1不均匀性和SAR恶化带来的限制，是高场MR的一项关键技术。该项目旨在通过创建自旋激励、射频设备和射频能量沉积的创新解决方案，显著提高人体高场MR的能力和安全性。这将通过以下方面的具体努力来实现：a）开发一种急需的非侵入性方法，用于测量、预测和主动管理SAR; B）利用该方法优化并行激励脉冲并开辟7 T MR应用的新领域;以及c）转换RF硬件和脉冲设计，以显著提高高场MR系统性能。 该项目的成功完成将导致定量/预测方法，使体内成像在高场，高影响身体成像应用中的全部潜力得以实现，以及创新的RF方法，有望将信号产生和检测性能提升到一个新的水平。