VOLUME REDUCTION IN HIPPOCAMPUS AND FRONTAL LOBE OF NONDEMENTED ELDERLY

无痴呆老人的海马体和额叶体积减小

• 批准号: 7955721
• 负责人: JEANYUNG CHEY
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955721
• 关键词: Age; Amygdaloid structure; Brain imaging; Cognition Disorders; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Education; Elderly; Funding; Grant; Hippocampus (Brain); Individual; Institution; Life; Magnetic Resonance Imaging; Medical; Memory; Memory Disorders; Modeling; Performance; Protocols documentation; Research; Research Personnel; Resources; Shapes; Slice; Source; Specific qualifier value; System; Thick; Time; United States National Institutes of Health; Weight; computational anatomy; frontal lobe; functional disability; interest; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Volume Reduction in Hippocampus and Frontal Lobe of Nondemented Elderly Individuals This study purports to examine the shape change in low cognitive performance elderly volunteers. The regions of interest are the hippocampus, the amygdala, and the frontal cortex. Twenty-eight normal volunteers were not demented and ¿normal¿based on the following criteria adjusted from a previous study: 1) free of cognitive disorders leading to functional impairments in everyday life, 2) live independently without difficulty, 3) absence of memory disorder, and 4) absence of psychiatric illness. The Low Cognitive Performance (LCP) group consisted of individuals whose performance was poor or borderline but was ¿normal¿according to the above criteria. Operational definition of LCP was scores less than one standard deviation below the mean compared to the age- and education-specified norms on the K-DRS or the Elderly Memory Scale (EMS). Brain images were acquired on a 1.5-T Signa system (General Electric Medical System, Milwaukee, WI, U.S.A.). The MRI protocol included the following: (a) sagittal T1-weighted acquisitions (repetition time [TR] 400, echo time [TE] 11, excitations 1) with field of view (FOV) of 24 cm, 5-mm slice thickness, and matrix size of 256 x 256; (b) T2-weighted acquisitions (TR 3,000, TE 100, excitations 2) in the coronal planes perpendicular to the long axis of the hippocampus with section thickness of 3 mm, FOV of 21 cm, and matrix size of 256 ¿ 256(c) coronal T1-weighted (TR 30, TE 7, excitation 1, flip angle 45¿¿) three-dimensional (3D) spoiled gradient acquisitions with 124 sections at 1.6-mm slice thickness, FOV of 21 cm, and matrix size of 256 ¿ 192.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 无需老年人的海马和额叶的体积减少 这项研究声称要检查低认知表现的形状变化。感兴趣的区域是海马，杏仁核和额叶皮层。根据以下研究调整的以下标准，二十八名正常志愿者没有痴呆，正常志愿者：1）没有认知障碍，导致日常生活中的功能障碍，2）独立生活，3）缺乏记忆障碍和4）缺乏精神病。低认知性能（LCP）组由表现较差或边缘线但按照上述标准为正常的个体组成。与K-DRS或老年人记忆量表（EMS）的年龄和教育指定规范相比，LCP的运行定义低于平均值低于平均值的一个标准偏差。大脑图像是在1.5-T Signa系统（美国威斯康星州密尔沃基的通用电气医疗系统）上获取的。 MRI协议包括以下内容：（a）矢状T1加权采集（重复时间[TR] 400，回声时间[TE] 11，兴奋1），视场（FOV）为24 cm，5 mm切片厚度，矩阵尺寸为256 x 256； （b）冠状平面垂直于垂直于海马长轴的冠状平面中T2加权的采集（TR 3,000，TE 100，兴奋2），截面厚度为3 mm，FOV为21 cm，矩阵的截面为21 cm，矩阵的大小为256€256€256（c）冠状T1-冠状T1-- tr 30，TR 30，TR 30，TE 7，TE 7，TE 7，ExciTement 1，ExcitErpecitement fane 7，Excitement fantement fant te 7，fant eccitim excitiim fane fantement fantement fant te 7，exciTement。 （3D）在1.6毫米切片厚度，21厘米的FOV和256¿192的基质大小为1.6毫米的梯度中损坏的梯度采集。