COBRE Center for Molecular Epidemiology

总体摘要 作为我们的生物医学研究卓越中心（COBRE）的一部分，我们创建了一个分子生物学中心。 流行病学在达特茅斯，支持招聘，职业发展和研究生产力的 有才华的初级研究人员在分子流行病学方面进行创新研究。这些多样化的教师 在我们中心的中心主题的共同利益：（1）应用国家的最先进的科学发现， 技术，以解决主要的健康问题，（2）确定疾病发病机制的早期指标和（3） 探索疾病病因和进展的共同途径。我们的成员跨越多个部门， 达特茅斯盖泽尔医学院、达特茅斯希区柯克医学中心和达特茅斯学院 艺术和科学。 据我们所知，在新英格兰没有其他的分子流行病学学术中心， 目前资助的COBREs侧重于全国的分子流行病学。作为COBRE的一部分，我们 将提供关键的分子流行病学研究基础设施， 新的发现和发现可以被翻译。这将通过四项独立研究来实现 项目与紧密交织的主题沿着一个国家的最先进的，多学科的生物储备核心和强大的 行政，职业发展和研究整合核心。建立在不断增加的 分子流行病学在新罕布什尔州，我们准备成为一个机构，地区和国家 在未来五年的分子流行病学研究的领导者，目标是：1）刺激创新 研究和促进初级研究人员的职业发展和招聘新的教师，2）促进 翻译关于疾病病因学共同途径的新兴技术和基础研究成果， 进展，和3）告知战略，以防止人类疾病的整个生命周期。因此，我们的中心 为分子流行病学提供关键的分子流行病学研究基础设施（例如，研究 设计方法学专业知识、人群风险因素和健康结果数据、生物样本和检测 创新的方法可以应用于这些领域，新的发现可以被转化。

OVERALL ABSTRACT As part of our Phase I Center of Biomedical Research Excellence (COBRE) we created a Center for Molecular Epidemiology at Dartmouth that supported the recruitment, career development, and research productivity of talented junior investigators carrying out innovative research in molecular epidemiology. These diverse faculty shared interests in our Center’s central themes of: (1) applying state-of-the-art scientific discoveries and technologies to address major health concerns, (2) identifying early indicators of disease pathogenesis and (3) exploring common pathways of disease etiology and progression. Our members span multiple departments in Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along a state-of-the-art, multidisciplinary Biorepository Core and strong Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to become an institutional, regional and national leader in molecular epidemiology research over the next five year with the goals of: 1) stimulating innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan. Thus, our Center for Molecular Epidemiology supplies the critical molecular epidemiology research infrastructure (e.g., research design methodology expertise, population risk factor and health outcome data, biologic specimens and assay results) to which innovative methods can be applied and new discoveries can be translated.