COBRE Center for Molecular Epidemiology

总体摘要 作为第一阶段生物医学研究卓越中心(COBRE)的一部分，我们创建了一个分子研究中心 支持招聘、职业发展和研究生产力的达特茅斯大学的流行病学 有才华的初级调查人员在分子流行病学方面进行创新研究。这些不同的教职员工 对我们中心的中心主题的共同兴趣：(1)应用最先进的科学发现和 解决主要健康问题的技术，(2)确定疾病发病的早期指标和(3) 探索疾病病因和进展的共同途径。我们的成员跨越多个部门 达特茅斯大学盖泽尔医学院、达特茅斯希区柯克医学中心和达特茅斯大学 文理科。 据我们所知，在新英格兰没有其他的分子流行病学学术中心，或者 目前资助的Cobres专注于全国的分子流行病学。作为拟议的Cobre的一部分，我们 将提供关键的分子流行病学研究基础设施，创新方法可以从这里 已应用的和新的发现可以被翻译。这将通过四项独立的研究来实现 主题紧密交织的项目，沿着最先进的、多学科的生物库核心和强大的 行政、职业发展和研究集成核心。建立在不断增长的 分子流行病学在新汉普郡，我们准备成为一个机构，地区和国家 未来五年分子流行病学研究的领导者，目标是：1)激发创新 研究和促进初级侦查员的职业发展和招聘新教师，2)促进 翻译关于疾病病因和常见途径的新兴技术和基础研究成果 进展，以及3)提供在整个生命周期内预防人类疾病的战略。因此，我们的中心 分子流行病学提供了关键的分子流行病学研究基础设施(例如，研究 设计方法专业知识、人口风险因素和健康结果数据、生物标本和化验 结果)，这些创新方法可以应用，新的发现可以转化为。

OVERALL ABSTRACT As part of our Phase I Center of Biomedical Research Excellence (COBRE) we created a Center for Molecular Epidemiology at Dartmouth that supported the recruitment, career development, and research productivity of talented junior investigators carrying out innovative research in molecular epidemiology. These diverse faculty shared interests in our Center’s central themes of: (1) applying state-of-the-art scientific discoveries and technologies to address major health concerns, (2) identifying early indicators of disease pathogenesis and (3) exploring common pathways of disease etiology and progression. Our members span multiple departments in Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along a state-of-the-art, multidisciplinary Biorepository Core and strong Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to become an institutional, regional and national leader in molecular epidemiology research over the next five year with the goals of: 1) stimulating innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan. Thus, our Center for Molecular Epidemiology supplies the critical molecular epidemiology research infrastructure (e.g., research design methodology expertise, population risk factor and health outcome data, biologic specimens and assay results) to which innovative methods can be applied and new discoveries can be translated.