COBRE Center for Molecular Epidemiology

总体摘要 作为我们第一阶段生物医学卓越研究中心 (COBRE) 的一部分，我们创建了一个分子中心 达特茅斯的流行病学支持了招聘、职业发展和研究生产力 有才华的初级研究人员在分子流行病学领域进行创新研究。这些多元化的师资力量 我们中心的中心主题具有共同的兴趣：（1）应用最先进的科学发现和 解决重大健康问题的技术，(2) 确定疾病发病机制的早期指标，以及 (3) 探索疾病病因和进展的共同途径。我们的成员跨越多个部门 达特茅斯盖塞尔医学院、达特茅斯希区柯克医学中心和达特茅斯学院 艺术和科学。 据我们所知，新英格兰没有其他分子流行病学学术中心，或者 目前资助的 COBRE 重点关注全国分子流行病学。作为拟议 COBRE 的一部分，我们 将提供关键的分子流行病学研究基础设施，从中可以采用创新方法 应用的新发现可以被转化。这将通过四项独立研究来实现 主题紧密交织的项目，沿着最先进的、多学科的生物样本库核心和强大的 行政、职业发展和研究整合核心。以不断增长的存在为基础 在新罕布什尔州的分子流行病学领域，我们准备成为一个机构、区域和国家 未来五年分子流行病学研究的领导者，目标是：1）刺激创新 研究和促进初级研究者的职业发展并招募新教师，2）促进 翻译关于疾病病因和常见途径的新兴技术和基础研究成果 进展，3) 提供在整个生命周期预防人类疾病的策略。因此，我们中心 分子流行病学提供了关键的分子流行病学研究基础设施（例如，研究 设计方法专业知识、人群风险因素和健康结果数据、生物标本和检测 结果），可以应用创新方法并转化新发现。

OVERALL ABSTRACT As part of our Phase I Center of Biomedical Research Excellence (COBRE) we created a Center for Molecular Epidemiology at Dartmouth that supported the recruitment, career development, and research productivity of talented junior investigators carrying out innovative research in molecular epidemiology. These diverse faculty shared interests in our Center’s central themes of: (1) applying state-of-the-art scientific discoveries and technologies to address major health concerns, (2) identifying early indicators of disease pathogenesis and (3) exploring common pathways of disease etiology and progression. Our members span multiple departments in Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along a state-of-the-art, multidisciplinary Biorepository Core and strong Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to become an institutional, regional and national leader in molecular epidemiology research over the next five year with the goals of: 1) stimulating innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan. Thus, our Center for Molecular Epidemiology supplies the critical molecular epidemiology research infrastructure (e.g., research design methodology expertise, population risk factor and health outcome data, biologic specimens and assay results) to which innovative methods can be applied and new discoveries can be translated.