Enhancing Alcoholism Pharmacotherapy Research via Behavioral Economics

通过行为经济学加强酒精中毒药物治疗研究

基本信息

批准号：
7866056
负责人：
JAMES MACKILLOP
金额：
$ 4.65万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-15 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7866056
关键词：
Alcohol consumption Alcohol dependence Alcoholism Alcohols Area Attenuated Award Basic Science Behavioral Blood Clinical Clinical Data Clinical Research Clinical Trials Data Development Doctor of Philosophy Economics Empirical Research Fostering Funding Future Individual Intervention Laboratories Limb structure Measures Mediating Mediator of activation protein Mentors Mentorship Methods Neurosciences Pharmaceutical Preparations Pharmacotherapy Placebos Principal Investigator Psychopharmacology Public Health Recruitment Activity Research Research Project Grants Research Training Sedation procedure Self Administration Training Translations alcohol craving alcoholism pharmacotherapy attenuation base career career development craving design improved novel patient oriented research pre-clinical research programs responsible research conduct sobriety topiramate

项目摘要

DESCRIPTION (provided by applicant): This proposal for a K23 Mentored Patient-Oriented Research Career Award is to provide James MacKillop, PhD, with the necessary mentorship and training to conduct high-quality research using behavioral economics to enhance research on pharmacotherapies for alcoholism. A behavioral economic approach may enhance pharmacotherapy research by focusing on medication effects on alcohol self-administration, facilitating mechanistic analyses, and providing greater translational consilience. The Career Development/Training Plan includes training in: 1) neuroscience and psychopharmacology; 2) laboratory methods for alcoholism pharmacotherapy research; 3) clinical methods for alcoholism pharmacotherapy research; 4) advanced training in behavioral economics; 5) professional development; 6) responsible conduct of research. The training will be overseen by a mentorship team comprised of Robert Swift, MD, PhD (Sponsor), Peter Monti, PhD (Co-Sponsor), Jennifer Tidey, PhD (Advisor), and Robert Miranda, Jr., PhD (Advisor). The training plan also proposes an empirical research project using behavioral economics to examine the effects of topiramate (TOP), a promising novel pharmacotherapy. The proposed study will recruit 60 alcohol dependent individuals who are not seeking treatment and study the effects of TOP under neutral conditions and during the ascending limb of the blood alcohol curve, using a 2 (TOP SOOmg/placebo) X 2 (neutral/ascending limb) mixed design. Based on its putative neuropharmacological actions and correlational clinical data, TOP is predicted to reduce alcohol self-administration on two behavioral economic measures. For exploratory purposes, the effects of TOP will also be examined during the descending limb of the blood alcohol curve. In addition to serving as criticial training; this research may have important clinical and methodological implications. RELEVANCE OF THE RESEARCH TO PUBLIC HEALTH: Medications for treating alcoholism have considerable promise and behavioral economics may enhance research in this area. This proposal is an application for a K23 Mentored Patient-Oriented Research Career Award for Dr. James MacKillop to gain the expertise to pursue this prospect, including mentorship, training, and an empirical study using behavioral economics to study topiramate, a promising new medication for alcoholism.

描述（由申请人提供）：针对K23指导的以患者为导向的研究职业奖的这一建议是为James Mackillop博士提供必要的指导和培训，以使用行为经济学进行高质量的研究，以增强对酒精中毒药物治疗的研究。行为经济方法可以通过专注于对酒精自我给药，促进机械分析并提供更大的转化合作率的药物影响来增强药物治疗研究。职业发展/培训计划包括：1）神经科学和心理药理学； 2）酒精中毒药物治疗研究的实验室方法； 3）酒精中毒药物治疗研究的临床方法； 4）行为经济学的高级培训； 5）专业发展； 6）负责任的研究。该培训将由由医学博士Robert Swift，博士（赞助商），彼得·蒙蒂（Peter Monti），博士（共同赞助人），詹妮弗·泰迪（Jennifer Tidey），博士（顾问）和小罗伯特·米兰达（Robert Miranda）组成的指导团队监督。该培训计划还提出了一个使用行为经济学的实证研究项目，以检查托吡酯（TOP）的影响，这是一种有希望的新型药物疗法。拟议的研究将招募60名不寻求治疗的饮酒的人，并研究顶部的影响中性条件以及在血液酒精曲线的上升肢体期间，使用2（顶部的SOOMG/安慰剂）x 2（中性/上升的肢体）混合设计。根据其推定的神经药理作用和相关临床数据，TOP预计将减少对两种行为经济措施的酒精自给自足。出于探索目的，还将在血液酒精曲线的降肢中检查顶部的效果。除了作为批评培训；这项研究可能具有重要的临床和方法学意义。研究与公共卫生的相关性：治疗酒精中毒的药物具有相当大的希望，行为经济学可能会增强该领域的研究。该提案是为詹姆斯·麦基洛普（James Mackillop）博士颁发了以患者为导向的研究职业奖的申请，以获得专业知识，以追求这一前景，包括指导，培训和使用行为经济学的实证研究来研究托吡酯，这是一种有希望的酒精中毒药物。