Behavioral Economic Trajectories of Alcohol Misuse in Emerging Adults: Neuroeconomic Augmentation via Electroencephalography

项目摘要/摘要 酒精滥用仍然是新兴成年人(18-25岁)的一个主要公共卫生问题。过度饮酒是 是这个年龄段的发病率和死亡率的最大来源，并预示着随后的酒精问题 在整个生命周期内。尽管大多数初出茅庐的成年人都从危险的饮酒中“成熟”出来，并过渡到 适度饮酒，许多人延续了酒精滥用的持续发展模式，而且 差异轨迹在很大程度上仍不得而知。大量的横断面研究发现 酒精滥用与行为经济学指数之间的显著关联，因此我们目前 将行为经济指标作为定期狂欢的过程进行纵向调查 饮酒者从20岁出头(21-24岁)到20岁左右(24-27岁)。然而，这项“父母”R01研究做了 不包括任何生物风险因素的测量，因此拟议的R21研究旨在收集 相隔8个月的两个时间点下子样本奖赏加工的神经生理学测量 在亲代纵向研究期间。神经生理学测量包括两个事件相关电位 与奖励处理紧密相关的(ERP)组件：(1)P3，反映激励 酒精相关刺激与非酒精刺激的显著程度，以及(2)奖励正性(RewP)，这将反映 对立即奖励和延迟奖励的敏感性。这些企业资源规划数据将使系统调查 ERPs作为持久性酒精风险的生物标志物，在现有的 文学。为了解决这个问题，这项研究将从现有研究中招募355名参与者完成 在已经安排好的研究访问期间进行额外的脑电检查。这项研究有两个主要目的。第一个目标 是将横断面神经生理测量整合到正在进行的纵向研究中，以检查 这些措施对单独和结合行为预测有问题的酒精使用的有效性 经济指标。第二个目标是确定纵向变化之间的对应关系 神经生理学和行为经济学风险指数及其与酒精滥用的关系。纵向 模型将被用来检验神经生理指标的变化是否导致了 随着时间的推移，酒精滥用，并理清重叠和独立的影响。

PROJECT SUMMARY/ABSTRACT Alcohol misuse remains a major public health problem in emerging adults (age 18-25). Excessive drinking is the largest source of morbidity and mortality in this age group and predicts subsequent alcohol problems across the lifespan. Although most emerging adults “mature out” of hazardous drinking and transition into moderate use, many continue a developmentally persistent pattern of alcohol misuse, and the predictors of differential trajectories remain largely unknown. A large number of cross-sectional studies have found significant associations between alcohol misuse and indices from behavioral economics, thus we are currently conducting a longitudinal investigation of behavioral economic indicators as processes in regular binge drinkers from their early twenties (21-24) to their mid-twenties (24-27). However, this “parent” R01 study does not include any measures of biological risk factors, so the proposed R21 study aims to collect neurophysiological measures of reward processing in a subsample at two timepoints spaced 8 months apart during the parent longitudinal study. The neurophysiological measures include two event-related potential (ERP) components that are robustly associated with reward processing: (1) P3, which reflects the incentive salience of alcohol-related vs. alcohol-free stimuli and (2) Reward Positivity (RewP), which will reflect sensitivity to immediate versus delayed reward. These ERP data would permit systematic investigation of the ERPs as biomarkers of persistent alcohol risk, a substantially understudied relationship in the existing literature. To address this question, the study will recruit 355 participants from the existing study to complete additional EEG sessions during already-scheduled study visits. This study has two primary aims. The first aim is to integrate cross-sectional neurophysiological measures into the ongoing longitudinal study to examine the utility of these measures to predict problematic alcohol use individually and in conjunction with behavioral economic indicators. The second aim is to determine correspondence between longitudinal changes in neurophysiological and behavioral economic indices of risk and their relations to alcohol misuse. Longitudinal models will be used to examine if changes in the neurophysiological indicators are responsible for changes in alcohol misuse over time and to disentangle overlapping versus independent influences.