Behavioral Economic Trajectories of Alcohol Misuse in Emerging Adults: Neuroeconomic Augmentation via Electroencephalography

项目概要/摘要 酒精滥用仍然是新兴成年人（18-25岁）的一个主要公共卫生问题。过量饮酒 这一年龄组发病率和死亡率的最大来源，并预测随后的酒精问题 在整个生命周期中。虽然大多数新兴的成年人“成熟”的危险饮酒和过渡到 适度使用，许多人继续发展持续的酒精滥用模式， 不同的轨迹仍然是未知的。大量的横断面研究发现， 酒精滥用和行为经济学指标之间存在显着关联，因此我们目前 对行为经济指标进行纵向调查，作为定期狂欢的过程 饮酒者从21-24岁到24-27岁。然而，这项“父”R 01研究确实 不包括生物风险因素的任何措施，因此拟议的R21研究旨在收集 在间隔8个月的两个时间点对子样本的奖励处理进行神经生理学测量 在父母纵向研究中。神经电生理测量包括两个事件相关电位 (ERP)与奖励处理密切相关的组成部分：（1）P3，反映了奖励 酒精相关与无酒精刺激的显着性和（2）奖励积极性（RewP），这将反映 对即时奖励和延迟奖励的敏感性。这些ERP数据将允许系统地调查 ERPs作为持续性酒精风险的生物标志物，在现有的研究中， 文学为了解决这个问题，该研究将从现有研究中招募355名参与者， 在已安排的研究访视期间进行额外的EEG会话。这项研究有两个主要目的。第一个目标 是将横截面神经生理学测量整合到正在进行的纵向研究中，以检查 这些措施的效用，以预测有问题的酒精使用个人和结合行为 经济指标。第二个目的是确定纵向变化之间的对应关系， 神经生理学和行为经济学风险指数及其与酒精滥用的关系。纵向 模型将用于检查神经生理学指标的变化是否导致 酒精滥用随着时间的推移，并解开重叠与独立的影响。

PROJECT SUMMARY/ABSTRACT Alcohol misuse remains a major public health problem in emerging adults (age 18-25). Excessive drinking is the largest source of morbidity and mortality in this age group and predicts subsequent alcohol problems across the lifespan. Although most emerging adults “mature out” of hazardous drinking and transition into moderate use, many continue a developmentally persistent pattern of alcohol misuse, and the predictors of differential trajectories remain largely unknown. A large number of cross-sectional studies have found significant associations between alcohol misuse and indices from behavioral economics, thus we are currently conducting a longitudinal investigation of behavioral economic indicators as processes in regular binge drinkers from their early twenties (21-24) to their mid-twenties (24-27). However, this “parent” R01 study does not include any measures of biological risk factors, so the proposed R21 study aims to collect neurophysiological measures of reward processing in a subsample at two timepoints spaced 8 months apart during the parent longitudinal study. The neurophysiological measures include two event-related potential (ERP) components that are robustly associated with reward processing: (1) P3, which reflects the incentive salience of alcohol-related vs. alcohol-free stimuli and (2) Reward Positivity (RewP), which will reflect sensitivity to immediate versus delayed reward. These ERP data would permit systematic investigation of the ERPs as biomarkers of persistent alcohol risk, a substantially understudied relationship in the existing literature. To address this question, the study will recruit 355 participants from the existing study to complete additional EEG sessions during already-scheduled study visits. This study has two primary aims. The first aim is to integrate cross-sectional neurophysiological measures into the ongoing longitudinal study to examine the utility of these measures to predict problematic alcohol use individually and in conjunction with behavioral economic indicators. The second aim is to determine correspondence between longitudinal changes in neurophysiological and behavioral economic indices of risk and their relations to alcohol misuse. Longitudinal models will be used to examine if changes in the neurophysiological indicators are responsible for changes in alcohol misuse over time and to disentangle overlapping versus independent influences.