Behavioral Economic Trajectories of Alcohol Misuse in Emerging Adults: Neuroeconomic Augmentation via Electroencephalography

新兴成年人酒精滥用的行为经济轨迹：通过脑电图增强神经经济

• 批准号: 9901827
• 负责人: JAMES MACKILLOP
• 金额: $ 20.6万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901827
• 关键词: Address; African American; Age; Alcohol abuse; Alcoholic beverage heavy drinker; Alcohols; Behavioral; Behavioral Mechanisms; Behavioral Model; Biological; Biological Markers; Cognitive; Cross-Sectional Studies; Cues; Data; Development; Economic Factors; Electroencephalography; Event-Related Potentials; Exhibits; Feedback; Foundations; Health; Heavy Drinking; Individual; Investigation; Joints; Knowledge; Legal; Literature; Longevity; Longitudinal Studies; Measures; Mediating; Mediation; Mediator of activation protein; Modeling; Morbidity - disease rate; Motivation; Parents; Participant; Pathway interactions; Pattern; Persons; Predictive Factor; Process; Psychological reinforcement; Public Health; Race; Rewards; Risk; Risk Factors; Schedule; Source; Stimulus; Testing; Time; United States; Visit; age group; alcohol cue; alcohol misuse; alcohol risk; behavior test; behavioral economics; behavioral study; binge drinker; biobehavior; cognitive neuroscience; cohort; college; discounting; drinking; economic indicator; emerging adult; hazardous drinking; incentive salience; indexing; mortality; neuroeconomics; neurophysiology; preference; recruit; relating to nervous system; response; reward processing; social; theories; young adult

PROJECT SUMMARY/ABSTRACT Alcohol misuse remains a major public health problem in emerging adults (age 18-25). Excessive drinking is the largest source of morbidity and mortality in this age group and predicts subsequent alcohol problems across the lifespan. Although most emerging adults “mature out” of hazardous drinking and transition into moderate use, many continue a developmentally persistent pattern of alcohol misuse, and the predictors of differential trajectories remain largely unknown. A large number of cross-sectional studies have found significant associations between alcohol misuse and indices from behavioral economics, thus we are currently conducting a longitudinal investigation of behavioral economic indicators as processes in regular binge drinkers from their early twenties (21-24) to their mid-twenties (24-27). However, this “parent” R01 study does not include any measures of biological risk factors, so the proposed R21 study aims to collect neurophysiological measures of reward processing in a subsample at two timepoints spaced 8 months apart during the parent longitudinal study. The neurophysiological measures include two event-related potential (ERP) components that are robustly associated with reward processing: (1) P3, which reflects the incentive salience of alcohol-related vs. alcohol-free stimuli and (2) Reward Positivity (RewP), which will reflect sensitivity to immediate versus delayed reward. These ERP data would permit systematic investigation of the ERPs as biomarkers of persistent alcohol risk, a substantially understudied relationship in the existing literature. To address this question, the study will recruit 355 participants from the existing study to complete additional EEG sessions during already-scheduled study visits. This study has two primary aims. The first aim is to integrate cross-sectional neurophysiological measures into the ongoing longitudinal study to examine the utility of these measures to predict problematic alcohol use individually and in conjunction with behavioral economic indicators. The second aim is to determine correspondence between longitudinal changes in neurophysiological and behavioral economic indices of risk and their relations to alcohol misuse. Longitudinal models will be used to examine if changes in the neurophysiological indicators are responsible for changes in alcohol misuse over time and to disentangle overlapping versus independent influences.

项目摘要/摘要 酒精遗产仍然是新兴成年人的主要公共卫生问题（18-25岁）。过多的饮酒是 该年龄段的发病率和死亡率的最大来源，并预测随后的酒精问题 在整个生命周期中 中等用途，许多人继续滥用酒精的持续持续模式，以及 差异轨迹在很大程度上仍然未知。大量横断面研究发现 滥用酒精与行为经济学指数之间的显着关联，因此我们目前是 作为常规狂欢的过程，对行为经济指标进行纵向调查 饮酒者从二十多岁（21-24）到二十多岁（24-27）。但是，这项“父母” R01研究确实 不包括生物危险因素的任何措施，因此拟议的R21研究旨在收集 在两个时间点间隔8个月的两个时间点，在子样本中的奖励处理的神经生理学度量 在父母纵向研究中。神经生理学措施包括两个与事件相关的电位 （ERP）与奖励处理牢固相关的组件：（1）P3，反映了激励措施 与酒精相关的无酒精刺激和（2）奖励阳性（REWP）的显着性，这将反映 对立即和延迟奖励的敏感性。这些ERP数据将允许对 ERP是持续酒精风险的生物标志物，现有 文学。为了解决这个问题，该研究将招募355名现有研究的参与者完成 在已经进行的研究访问期间的其他脑电图课程。这项研究有两个主要目标。第一个目标 是将横断面神经生理学措施整合到正在进行的纵向研究中，以检查 这些措施的实用性可以单独预测有问题的酒精使用，并结合行为 经济指标。第二个目的是确定纵向变化之间的对应关系 风险的神经生理和行为经济指数及其与滥用酒精的关系。纵向 模型将用于检查神经生理指标的变化是否导致变化 随着时间的流逝，酒精滥用，以解散重叠与独立影响。