Using Neuroeconomics to Understand Alcohol Overvaluation in Alcohol Use Disorder

项目概要/摘要 神经经济学这个新领域整合了心理学、经济学和心理学的概念和方法。 认知神经科学来理解决策的神经生物学基础，并且已经 越来越多地应用于理解酒精使用障碍（AUD）。神经经济学的一个新焦点是酒精 需求，或通过成本效益偏好衡量的酒精价值。从行为上看，酒精需求已 被发现在酗酒程度较高的个体中升高并预测治疗 回应。此外，酒精需求也会因急性压力而动态增加。这些发现是 与强调稳定强直和急性阶段方面的理论观点一致 动机。拟议研究的总体目标是表征促进这些的神经活动 使用新颖的功能磁共振成像范例建立了行为发现。第一个目标是 与对照组相比，检查 AUD 患者的大脑如何代表酒精的价值。 为此，第一项研究将使用受试者间病例对照设计来识别神经活动的差异 与饮酒者相比，澳元患者（即病例）的酒精需求增加相关 定期但没有 AUD，并且在关键变量（即控制）上进行匹配。第二个目标是 研究与压力引起的酒精价值增加相关的神经活动变化。要做的事 因此，第二项研究将使用受试者内设计，比较需求相关的神经活动 AUD 患者应激诱导后神经活动的中性诱导。第三个目标是 研究酒精需求决策过程中神经活动模式之间的关系 干预反应。为此，所有在研究 #1 和研究 #2 中持有 AUD 的参与者都将获得激励 增强疗法是一种先前经过验证的四次手动动机访谈干预措施， 酒精需求范式期间的神经活动将用于预测 1 个月后的后续饮酒情况 和 6 个月的随访。总的来说，这些目标将系统地应用一种新颖的神经经济学方法 AUD 跨转化谱的各个方面，从神经活动的基本差异到预测因子 的干预反应。

PROJECT SUMMARY/ABSTRACT The novel field of neuroeconomics integrates concepts and methods from psychology, economics, and cognitive neuroscience to understand the neurobiological foundations of decision making, and has been increasingly applied to understanding alcohol use disorder (AUD). A novel focus in neuroeconomics is alcohol demand, or the value of alcohol as measured by cost-benefit preferences. Behaviorally, alcohol demand has been found to be elevated among individuals with higher levels of alcohol misuse and to predict treatment response. In addition, alcohol demand can also be dynamically increased via acute stress. These findings are consistent with theoretical perspectives that emphasize both stable tonic and acute phasic aspects of motivation. The overall goal of the proposed studies is to characterize the neural activity that subserves these established behavioral findings using a novel functional magnetic resonance imaging paradigm. The first aim is to examine how the brain represents the value of alcohol in individuals with AUD compared to a control group. To do so, the first study will use a between-subjects case-control design to identify differences in neural activity associated with elevations in alcohol demand in individuals with AUD (i.e., cases) versus individuals who drink regularly but do not have an AUD and are matched on key variables (i.e., controls). The second aim is to investigate the changes in neural activity associated with stress-elicited increases in the value of alcohol. To do so, a second study will use a within-subjects design, comparing demand-associated neural activity following a neutral induction to neural activity following a stress induction in individuals with AUD. The third aim is to investigate the relationship between patterns of neural activity during alcohol demand decision making and intervention response. To do so, all participants with AUD in Study #1 and Study #2 will receive Motivational Enhancement Therapy, a previously validated four-session manualized motivational interviewing intervention, and neural activity during the alcohol demand paradigm will be used to predict subsequent drinking at 1-month and 6-month follow-up. Collectively, these aims will systematically apply a novel neuroeconomic approach to diverse aspects of AUD across the translational spectrum, from basic differences in neural activity to predictors of intervention response.