EVOLUTION, RECOMBINATION AND EMERGENCE OF SIMIAN RETROVIRUSES IN BANGLADESH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多种灵长类动物，包括5种猕猴（Macacamulatta，M. nemestrina，M.束状孢M. assamensis、M.在世界上人口最稠密的国家之一孟加拉国，有3种叶猴（Semnopithecusentellus，Trachypithecusphayrei，Trachypithecuspileatus）与人类在不同的地区和生态环境（城市灵长类、寺庙灵长类、野生动物市场、宠物灵长类、野生灵长类）中共存。这种共存为人与灵长类动物的相互作用提供了充足的机会，并构成了感染性病原体跨物种传播的风险。本研究旨在探讨猴泡沫病毒（SFV）和猴D型逆转录病毒（SRV）在猕猴和叶猴中的流行病学、生态学和进化。我们还将测量暴露于猕猴和叶猴的个体中SFV和SRV的人类感染率，并描述跨物种传播如何导致病毒重组和进化。所有这些因素对于理解新的逆转录病毒人畜共患病的潜在出现都是重要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple primate species, including 5 species of macaques (Macaca mulatta, M. nemestrina, M. fascicularis, M. assamensis, M. arctoides) and 3 species of langurs (Semnopithecus entellus, Trachypithecus phayrei, Trachypithecus pileatus) coexist with humans in different areas and ecological contexts (urban primates, temple primates, wildlife markets, pet primates, wild primates) in Bangladesh, one of the most densely populated countries in the world. This coexistence provides ample opportunity for human-primate interaction and poses a risk for cross-species transmission of infectious agents. Our proposed research will investigate the epizootiology, ecology and evolution of two simian retroviruses, simian foamy virus (SFV) and simian type D retrovirus (SRV) in macaques and langurs. We will also measure the prevalence of human infection with SFV and SRV among individuals exposed to macaques and langurs and describe how cross-species transmission may lead to viral recombination and evolution. All of these factors are important for the understanding of the potential emergence of new retroviral zoonotic disease(s).