EVOLUTION, RECOMBINATION AND EMERGENCE OF SIMIAN RETROVIRUSES IN BANGLADESH

孟加拉国猴逆转录病毒的进化、重组和出现

• 批准号: 8172627
• 负责人: LISA E JONES-ENGEL
• 金额: $ 15.21万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172627
• 关键词: Area; Bangladesh; Computer Retrieval of Information on Scientific Projects Database; Country; Disease; Ecology; Evolution; Funding; Genetic Recombination; Grant; Human; Individual; Infection; Infectious Agent; Institution; Langurs; Lead; Macaca; Macaca mulatta; Marketing; Measures; Prevalence; Primates; Research; Research Personnel; Resources; Risk; Simian Foamy Virus; Simian Retroviruses; Source; Type D Retrovirus; United States National Institutes of Health; Viral; epizootiology; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple primate species, including 5 species of macaques (Macaca mulatta, M. nemestrina, M. fascicularis, M. assamensis, M. arctoides) and 3 species of langurs (Semnopithecus entellus, Trachypithecus phayrei, Trachypithecus pileatus) coexist with humans in different areas and ecological contexts (urban primates, temple primates, wildlife markets, pet primates, wild primates) in Bangladesh, one of the most densely populated countries in the world. This coexistence provides ample opportunity for human-primate interaction and poses a risk for cross-species transmission of infectious agents. Our proposed research will investigate the epizootiology, ecology and evolution of two simian retroviruses, simian foamy virus (SFV) and simian type D retrovirus (SRV) in macaques and langurs. We will also measure the prevalence of human infection with SFV and SRV among individuals exposed to macaques and langurs and describe how cross-species transmission may lead to viral recombination and evolution. All of these factors are important for the understanding of the potential emergence of new retroviral zoonotic disease(s).

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在世界上人口最稠密的国家之一的孟加拉国，多种灵长类动物与人类共存，其中包括5种猕猴(猕猴、M.nomestrina、M.Fascular aris、M.assamens、M.arctoides)和3种叶猴(Semnopithecus entellus、Trachypithecus phayrei、Trachypithecus Pileatus)，它们与人类在不同的地区和生态环境(城市灵长类、寺庙灵长类、野生动物市场、宠物灵长类和野生灵长类)共存。这种共存为人与灵长类动物的相互作用提供了充足的机会，并对传染病病原体的跨物种传播构成了风险。我们的研究将调查猕猴和叶猴体内两种逆转录病毒--猿猴泡沫病毒(SFV)和猿猴D型逆转录病毒(SRV)的流行病学、生态学和进化。我们还将测量接触猕猴和叶猴的个体中人类感染SFV和SRV的流行率，并描述跨物种传播如何导致病毒重组和进化。所有这些因素对于理解新的逆转录病毒人畜共患病的潜在出现都很重要(S)。