SYNANTHROPY AND HEALTH IN ASIA: DISEASE IMPLICATIONS OF A SHARED ENVIRONMENT

亚洲的协同与健康：共享环境对疾病的影响

• 批准号: 8172778
• 负责人: LISA E JONES-ENGEL
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172778
• 关键词: Adolescent; Asia; Bangladesh; Centers for Disease Control and Prevention (U.S.); Computer Retrieval of Information on Scientific Projects Database; Disease; Emerging Communicable Diseases; Enterovirus; Environment; Evolution; Funding; Grant; Health; Human; Institution; Lead; Macaca; Measures; Mercury; Micronutrients; Nutritional; Nutritional status; Population; Prevalence; Primates; Publishing; Research; Research Personnel; Resources; Sampling; Sentinel; Source; Taxon; Testing; Time; United States National Institutes of Health; Vitamin A; Zinc; exposed human population; immune function; international center; lead exposure; nonhuman primate; pathogen; toxicant; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Emerging Infectious Disease (EID) Core of the Primate Center's International Division has been characterizing the interspecies transmission of enteroviruses between humans and nonhuman primates in Bangladesh since 2006. Our collaborating CDC researchers previously isolated several enterovirus strains, EV76, EV89, EV90, and EV91, from humans in Bangladesh that closely resemble primate enteroviruses characterized in the 1950-70's. To date, we have analyzed more than 750 samples from 13 synanthropic (they share an ecological niche with humans) NHP taxa using real-time PCR and typed by VP1 sequencing. Overall enteroviral prevalence in this s sample was 8.6%, including 22 distinct enterovirus strains, several that have been identified as pathogenic in humans. Distribution of enteroviruses is characterized almost entirely by ecological context and enteroviruses present within an ecological context are not host specific. This has important implications for the evolution and emergence of pathogens. The EID core has also been investigating nutritional parameters and ecotoxicology in free ranging populations of NHPs in Asia. Ongoing research is measuring levels of micronutrients, such as Zinc and Vitamin A (this research tests the hypotheses that nutritional status impacts immune function in populations of free ranging macaques), as well as toxicants like lead and mercury. Recently, we published evidence that free-ranging juvenile macaques may be appropriate sentinels for human exposure to lead.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 自2006年以来，灵长类中心国际部的新兴传染病核心一直在描述孟加拉国人类和非人灵长类动物之间肠道病毒的种间传播。我们合作的CDC研究人员先前从孟加拉国的人类中分离出几种肠道病毒株，EV 76，EV 89，EV 90和EV 91，它们与20世纪50 -70年代的灵长类肠道病毒非常相似。到目前为止，我们已经分析了超过750个样本，从13个合生（他们与人类共享一个生态位）NHP类群使用实时PCR和类型的VP 1测序。该样本中肠道病毒的总体流行率为8.6%，包括22种不同的肠道病毒株，其中几种已被确定为人类致病性。肠道病毒的分布特征几乎完全取决于生态环境，并且存在于生态环境中的肠道病毒不是宿主特异性的。这对病原体的进化和出现具有重要意义。 EID核心还一直在调查亚洲自由放养的NHP群体的营养参数和生态毒理学。 正在进行的研究正在测量微量营养素的水平，如锌和维生素A（这项研究测试了营养状况影响自由放养猕猴群体免疫功能的假设），以及铅和汞等有毒物质。最近，我们发表的证据表明，自由放养的少年猕猴可能是人类接触铅的适当哨兵。