Role of immature myeloid cells in premetastatic lung

未成熟骨髓细胞在转移前肺中的作用

• 批准号: 7966143
• 负责人: Li Yang
• 金额: $ 36.5万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966143
• 关键词: Cells; Data; Distant; Environment; Goals; ITGAM gene; Immune; Inflammatory; Integration Host Factors; Lung; Mammary Neoplasms; Molecular; Mus; Myeloid Cells; Neoplasm Metastasis; Organ; Phase; Predisposition; Production; Role; chemokine; cytokine; interest; neoplastic cell; tumor

Since moved here in January of 2009, we have been able to continue to produce very interesting data in this project. We have found that the immature myeloid cells arrive prior to tumor cells in distant lung in the breast tumor bearing mice. They significantly alter the production of multiple cytokine and chemokine production. Our data suggest that Gr-1+CD11b+ cells alter premetastatic lung into an inflammatory and proliferative environment, diminish immune protection and promote metastasis through aberrant vasculature formation.

自从2009年1月搬到这里以来，我们一直能够继续在这个项目中产生非常有趣的数据。我们发现，在乳腺荷瘤小鼠的远端肺中，未成熟的髓样细胞先于肿瘤细胞到达。它们显著地改变了多种细胞因子和趋化因子的产生。我们的数据表明，Gr-1+CD11b+细胞将转移前肺改变为炎症和增殖环境，减少免疫保护，并通过异常的脉管系统形成促进转移。