Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta

过去一年，我们取得了稳步进展。我们已经生产和培育了TGFbeta R2受体在宿主未成熟骨髓细胞中特异性缺失的小鼠菌落。我们观察到骨髓TGFbeta R2小鼠的肿瘤进展明显减少。我们获得了涉及全身免疫反应的机制，以及骨髓细胞与微环境和远处转移器官中的肿瘤细胞的直接相互作用。我们已经确定miRNA130a和miRNA145直接靶向髓系TGFbeta R2及其相关的IGFR通路信号网络。我们希望利用获得的研究信息开发新的转化机会。我们正在利用技术核心资源，并与几个实验室合作进行这个项目。

We have made steady progress in the past year. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We obtained mechanistic insight that involves systemic immune response as well as direct interaction of myeloid cells with tumor cells in the microenvironment and distant metastatic organ. We have identified that miRNA130a and miRNA145 directly target myeloid TGFbeta R2 and its associated signaling networks the IGFR pathway. We hope to develop new translational opportunities with the research information obtained. We are utilizing technical core resources and collaborating with several labs for this project.