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Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta

Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
宿主未成熟骨髓细胞中 TGFbeta 的肿瘤抑制或启动子作用
批准号：
8937987
负责人：
Li Yang
金额：
$80.67万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8937987
关键词：
BreedingCancer BiologyDiseaseDistantEpithelial CellsFibroblastsGeneticGoalsHumanImmune responseMalignant - descriptorMalignant NeoplasmsMediator of activation proteinModelingMolecularMusMyelogenousMyeloid CellsNeoplasm MetastasisOncogenicOrganPhenotypePremalignantRegulationResearchResearch PersonnelResourcesRoleSignal PathwaySignal TransductionStagingStrategic PlanningTransforming Growth Factor betaTumor PromotersTumor Suppressor ProteinsWorkYangcancer therapyinsightmouse modelneoplastic cellpromoterreceptortumortumor progressiontumorigenesis

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英文摘要
We have made steady progress in the past year. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as direct interaction of myeloid cells with tumor cells in the microenvironment and distant metastatic organ. We hope to develop new translational opportunities with the research information obtained. We are utilizing technical core resources and collaborating with several labs for this project.
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