Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
批准号:
8157666
负责人:
Li Yang
金额:
$60.67万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
作为2009年成立的新实验室,我们已经能够聘请有才华的博士后和研究生从事这个项目。我们已经生产和培育了TGFbeta R2受体在肿瘤细胞或宿主未成熟骨髓细胞中特异性缺失的小鼠菌落。我们观察到骨髓TGFbeta R2小鼠的肿瘤进展明显减少。我们目前正在研究包括全身免疫反应和肿瘤微环境在内的机制。我们正在利用技术核心资源,并与几个实验室合作进行这个项目。
英文摘要
As a new lab starting in 2009, we have been able to hire talented postdoc and graduate students working on this project. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in tumor cells or host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as tumor microenvironment. We are utilizing technical core resources and collaborating with several labs for this project.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Evaluate the Role and Mechanism of GPR4 in Immunotherapy-Related Colitis
-
批准号:10580825
-
项目类别:
-
资助金额:$7.55万
-
财政年份:2022
-
负责人:Li Yang
-
依托单位:
Evaluate the Role and Mechanism of GPR4 in Immunotherapy-Related Colitis
-
批准号:10437296
-
项目类别:
-
资助金额:$7.55万
-
财政年份:2022
-
负责人:Li Yang
-
依托单位:
Dissect the Timing Mechanism for Immune Maturation in Plants
-
批准号:10672250
-
项目类别:
-
资助金额:$34.92万
-
财政年份:2021
-
负责人:Li Yang
-
依托单位:
Dissect the Timing Mechanism for Immune Maturation in Plants
-
批准号:10441597
-
项目类别:
-
资助金额:$34.94万
-
财政年份:2021
-
负责人:Li Yang
-
依托单位:
Dissect the Timing Mechanism for Immune Maturation in Plants
-
批准号:10276940
-
项目类别:
-
资助金额:$34.96万
-
财政年份:2021
-
负责人:Li Yang
-
依托单位:
Role of immature myeloid cells in premetastatic lung
-
批准号:8349363
-
项目类别:
-
资助金额:$28.05万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Roles of tumor suppressors (TSs) in metastatic progression
-
批准号:10926149
-
项目类别:
-
资助金额:$90.08万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Role of inflammation in epigenetic alterations of metastatic cancer cells
-
批准号:10262250
-
项目类别:
-
资助金额:$98.55万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Role of immature myeloid cells in premetastatic lung
-
批准号:7966143
-
项目类别:
-
资助金额:$36.5万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Role of inflammation in epigenetic alterations of metastatic cancer cells
-
批准号:9153803
-
项目类别:
-
资助金额:$57.02万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Roles of tumor suppressors (TSs) in metastatic progression
-
批准号:10702492
-
项目类别:
-
资助金额:$100.18万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
-
批准号:10262249
-
项目类别:
-
资助金额:$98.55万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Role of immature myeloid cells in premetastatic lung
-
批准号:8157667
-
项目类别:
-
资助金额:$40.45万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Role of immature myeloid cells in premetastatic lung
-
批准号:8763377
-
项目类别:
-
资助金额:$32.32万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
-
批准号:8349362
-
项目类别:
-
资助金额:$65.44万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
-
批准号:8937987
-
项目类别:
-
资助金额:$80.67万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
-
批准号:7966136
-
项目类别:
-
资助金额:$54.76万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Myeloid TGFbeta signaling in breast cancer metastasis
-
批准号:10926148
-
项目类别:
-
资助金额:$90.08万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
-
批准号:9343824
-
项目类别:
-
资助金额:$92.11万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
Myeloid TGFbeta signaling in breast cancer metastasis
-
批准号:10702491
-
项目类别:
-
资助金额:$100.18万
-
财政年份:--
-
负责人:Li Yang
-
依托单位:
海外基金