Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta

宿主未成熟骨髓细胞中 TGFbeta 的肿瘤抑制或启动子作用

• 批准号: 8157666
• 负责人: Li Yang
• 金额: $ 60.67万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157666
• 关键词: Myeloid Cells; Role; Transforming Growth Factor beta; Tumor Suppressor Proteins; promoter

As a new lab starting in 2009, we have been able to hire talented postdoc and graduate students working on this project. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in tumor cells or host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as tumor microenvironment. We are utilizing technical core resources and collaborating with several labs for this project.

作为2009年成立的新实验室，我们已经能够聘请有才华的博士后和研究生从事这个项目。我们已经生产和培育了TGFbeta R2受体在肿瘤细胞或宿主未成熟骨髓细胞中特异性缺失的小鼠菌落。我们观察到骨髓TGFbeta R2小鼠的肿瘤进展明显减少。我们目前正在研究包括全身免疫反应和肿瘤微环境在内的机制。我们正在利用技术核心资源，并与几个实验室合作进行这个项目。