Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
Host immature myeloid cells in tumor suppressor or promoter roles of TGFbeta
批准号:
8157666
负责人:
Li Yang
金额:
$60.67万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
作为一个从2009年开始的新实验室,我们已经能够聘请到有才华的博士后和研究生参与这个项目。我们已经创造和培育了肿瘤细胞或宿主未成熟髓系细胞中TGFbeta R2受体特异性缺失的小鼠克隆。我们观察到髓系TGFbeta R2 Ko小鼠的肿瘤进展显著减缓。我们目前正在研究涉及全身免疫反应以及肿瘤微环境的机制。我们正在利用技术核心资源,并为这个项目与几个实验室合作。
英文摘要
As a new lab starting in 2009, we have been able to hire talented postdoc and graduate students working on this project. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in tumor cells or host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as tumor microenvironment. We are utilizing technical core resources and collaborating with several labs for this project.
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