Immune cell interactions and cell signalling pathways important for rotavirus infection

免疫细胞相互作用和细胞信号传导途径对轮状病毒感染很重要

• 批准号: nhmrc : 509006
• 负责人: A/Pr Barbara Coulson
• 金额: $ 22.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-cell-interactions-rotavirus-infection/99094
• 关键词: Immune; cell; interactions; signalling; pathways

Rotaviruses are the main cause of severe diarrhoea in Australian children, through infection of the gut cells that absorb food. This project aims to understand the effects of rotaviruses on the functioning and survival of these cells at the molecular level. It will similarly determine the effects of rotavirus infection on the immune cells. These studies will increase understanding of how rotaviruses cause disease, and assist in the development of drugs or improved vaccines against rotavirus.

轮状病毒是澳大利亚儿童严重腹泻的主要原因，通过感染吸收食物的肠道细胞。该项目旨在从分子水平上了解轮状病毒对这些细胞的功能和存活的影响。它将类似地确定轮状病毒感染对免疫细胞的影响。这些研究将增加对轮状病毒如何引起疾病的理解，并有助于开发针对轮状病毒的药物或改进的疫苗。