Elucidating the pathogenic role of rotavirus infection in type 1 diabetes development

阐明轮状病毒感染在 1 型糖尿病发展中的致病作用

• 批准号: nhmrc : 1044868
• 负责人: A/Pr Barbara Coulson
• 金额: $ 35.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-pathogenic-role-diabetes-development/111695
• 关键词: Elucidating; pathogenic; role; rotavirus; infection

Rotavirus infection is the main cause of severe diarrhoea in children, and has been implicated in accelerated progression of genetically at-risk children towards type 1 diabetes in two independent studies. My group has further discovered that rotavirus also accelerates diabetes onset in mice in a novel immunological process. In this project, we will determine the mechanism behind this disease exacerbation in the mice, to facilitate understanding of the process in children.

轮状病毒感染是儿童严重腹泻的主要原因，两项独立研究表明，轮状病毒感染与基因上有风险的儿童加速发展为1型糖尿病有关。我的小组进一步发现轮状病毒还通过一种新的免疫过程加速了小鼠糖尿病的发病。在这个项目中，我们将确定这种疾病在小鼠中恶化的机制，以促进对儿童过程的理解。