Understanding how virus infection accelerates type 1 diabetes development

了解病毒感染如何加速 1 型糖尿病的发展

• 批准号: nhmrc : 1103279
• 负责人: A/Pr Barbara Coulson
• 金额: $ 41.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-virus-infection-diabetes-development/662669
• 关键词: Understanding; how; virus; infection; accelerates

We linked rotavirus infection in children at-risk of type 1 diabetes with faster diabetes development. A heightened response to the virus is implicated by our mouse model studies. We will determine if more rapid mouse diabetes due to rotavirus requires this heightened response, and if this response is also made by cells from diabetes patients after stimulation with rotavirus or other relevant viruses. These studies are vital to learn how viruses affect type 1 diabetes and devise interventions.

我们将1型糖尿病风险儿童的轮状病毒感染与糖尿病的快速发展联系起来。我们的小鼠模型研究暗示了对病毒的高度反应。我们将确定轮状病毒引起的更快速的小鼠糖尿病是否需要这种增强的反应，以及在轮状病毒或其他相关病毒刺激后，糖尿病患者的细胞是否也会产生这种反应。这些研究对于了解病毒如何影响1型糖尿病和设计干预措施至关重要。