Glycan specificity and dependence in rotavirus host cell invasion

轮状病毒宿主细胞侵袭中的聚糖特异性和依赖性

• 批准号: nhmrc : 597439
• 负责人: A/Pr Barbara Coulson
• 金额: $ 42.45万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycan-specificity-dependence-cell-invasion/101047
• 关键词: Glycan; specificity; dependence; rotavirus; host

Rotavirus is a global pathogen that causes acute gastroenteritis resulting in dehydration and high levels of infant mortality. Annually, infections cause 138 million cases of infantile gastroenteritis and an estimated average of 600,000 deaths. Within Australia ~10,000 children under 5 yrs old are admitted to hospital annually with severe rotavirus-induced diarrhoea. This project will investigate the role of carbohydrates in rotavirus infection to help design new vaccines and inhibitors.

轮状病毒是一种全球性病原体，可引起急性胃肠炎，导致脱水和高水平的婴儿死亡率。每年，感染导致1.38亿婴儿胃肠炎病例，估计平均死亡60万人。在澳大利亚，每年约有10,000名5岁以下儿童因轮状病毒引起的严重腹泻入院。该项目将研究碳水化合物在轮状病毒感染中的作用，以帮助设计新的疫苗和抑制剂。