Innate immune responses to rotavirus infection

对轮状病毒感染的先天免疫反应

• 批准号: nhmrc : 1023786
• 负责人: A/Pr Barbara Coulson
• 金额: $ 35.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/innate-immune-responses-rotavirus-infection/110304
• 关键词: Innate; immune; responses; rotavirus; infection

Rotavirus is the main cause of severe diarrhoea in children worldwide. In this project, we aim to understand the nature of the first-line immune response to rotavirus in the gut, and elucidate how RV counteracts this response to promote infection. These studies will increase our understanding of how rotavirus causes disease, and facilitate the choice of rotavirus targets for drug development and improved vaccines.

轮状病毒是全世界儿童严重腹泻的主要原因。在这个项目中，我们的目标是了解肠道中对轮状病毒的一线免疫反应的性质，并阐明RV如何抵消这种反应以促进感染。这些研究将增加我们对轮状病毒如何引起疾病的理解，并促进轮状病毒药物开发和改进疫苗靶点的选择。