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Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents

用于测量环境因素内部剂量的紧凑型化学传感器

基本信息

批准号：
7801206
负责人：
Richard H Clarke
金额：
$ 9.99万
依托单位：
AGILTRON, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-10 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7801206
关键词：
Acetylcholinesterase Adopted Allergens Aromatic Polycyclic Hydrocarbons Biological Blood Blood Circulation Blood Tests Blood specimen Chemical Agents Chemical Warfare Agents Chemicals Chemistry Clinical Computer software Coupled Cyanides Databases Detection Devices Diagnosis Dose Drops Early Diagnosis Event Exposure to Fingers Gel Generations Glucose Gold Home environment Hospitals Housing Individual Industrial Accidents Lasers Libraries Life Light Literature Marketing Measurement Measures Methods Microprocessor Modeling Molds Monitor National Institute of Environmental Health Sciences Nature Optics Organic Chemicals Organophosphorus Compounds Patients Persons Pesticides Pharmaceutical Preparations Pharmacologic Substance Plastics Poison Population Preparation Process Proteins Raman Spectrum Analysis Reader Reporting Request for Proposals Resolution Resources Saliva Sampling Severities Site Small Business Innovation Research Grant Source Steroids Surface Surveys System Techniques Technology Testing Time Toxin Urine analytical method base cost design environmental agent environmental chemical glucose monitor instrument interest light scattering microbial nerve agent novel operation particle programs prototype public health relevance response sensor tool toxic industrial chemical toxicant volatile organic compound wasting

项目摘要

DESCRIPTION (provided by applicant): Detection of exposure to environmental agents by measurement of internal dose of such agents or their metabolites, chemical or biological, requires rapid assessment and identification of exposure to both known and unknown threats. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of the exposure and save many lives by enabling and adopting protective measures. The ideal detection device is one that is small, portable, easy to use and capable of rapid analysis in the field. The levels of toxicants should be easily obtained from a convenient biosample (blood, urine, etc) for rapid determination of the internal dose of the agent, with a minimum of false positives and false negatives to avoid wasting resources and missing actual exposure problems. We propose to build a portable, field- deployable blood test monitor to immediately identify toxic chemical agent buildup in persons suspected of having been exposed to such agents. The technology we plan to utilize is surface-enhanced Raman scattering, based on a well-known inelastic laser light scattering analytical technique for precise lab identification of organic compounds to look for the presence of environmental agents directly as trace contaminants in the bloodstream (or, potentially, in urine or saliva samples, as well). The proposed system is comprised of a low- resolution Raman detection unit coupled to a strip reader that analyzes a drop of blood placed on a gold sol-gel strip. The low-resolution surface-enhanced Raman spectrum (SERS) obtained from the blood drop on the strip is compared with a spectral peak library in the unit for analysis of the presence and concentration of specific chemical components present in the patient's blood. In overview, the unit operates much like a commercial handheld glucose meter and other at-home test kits for individual blood analytes, well known for home diagnosis of patient glucose levels, but now set up for analysis of a range of blood analytes in a single device. PUBLIC HEALTH RELEVANCE: The Company believes significant markets exist for portable, field-deployable products for on-site blood analysis based on the designs created and tested in the present SBIR program. As a practical example, the Company anticipates that persons taking prescription medications that require regular monitoring for effective dose level may benefit from the present Raman approach. In this application, the drug or its metabolite might be monitored in a blood sample by SERS at regular intervals at home for compliance and adjustment of the medication, as required.

说明（由申请方提供）：通过测量环境物剂或其代谢物（化学或生物）的体内剂量来检测环境物剂的暴露，需要快速评估和识别已知和未知威胁的暴露。快速检测和识别暴露于此类威胁的情况，可以及时警告暴露的程度和严重性，并通过启用和采取保护措施挽救许多生命。理想的检测设备是体积小、便携、易于使用并能够在现场进行快速分析的设备。有毒物质的水平应该很容易从方便的生物样品（血液，尿液等）中获得，以快速确定药剂的内部剂量，并将假阳性和假阴性降至最低，以避免浪费资源和错过实际暴露问题。我们建议建立一个便携式，现场部署的血液检测监测器，以立即识别有毒化学制剂积累的人怀疑已暴露于这种代理。我们计划利用的技术是表面增强拉曼散射，基于众所周知的非弹性激光散射分析技术，用于精确的实验室鉴定有机化合物，以寻找环境因子的存在，直接作为血液中的痕量污染物（或者，也可能是尿液或唾液样本）。所提出的系统由耦合到条读取器的低分辨率拉曼检测单元组成，所述条读取器分析放置在金溶胶-凝胶条上的一滴血。将从条带上的血滴获得的低分辨率表面增强拉曼光谱（Sers）与单元中的光谱峰库进行比较，以分析患者血液中存在的特定化学成分的存在和浓度。总的来说，该装置的操作非常类似于商用手持式血糖仪和其他用于单个血液分析物的家用测试套件，众所周知，用于患者血糖水平的家庭诊断，但现在设置为在单个设备中分析一系列血液分析物。公共卫生相关性：该公司认为，基于目前SBIR计划中创建和测试的设计，便携式现场部署产品的现场血液分析存在重要市场。作为一个实际的例子，该公司预计，服用处方药，需要定期监测有效剂量水平的人可能会受益于目前的拉曼方法。在这种应用中，药物或其代谢物可以在家中通过Sers定期监测血液样品中的药物或其代谢物，以根据需要进行药物的依从性和调整。