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Quick-Set Endodontic Material

快装牙髓材料

基本信息

批准号：
7997278
负责人：
Carolyn Margaret Primus
金额：
$ 10万
依托单位：
PRIMUS CONSULTING
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2011-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7997278
关键词：
Acids Animal Testing Base Composition Biological Calcium Cells Clinical Consult Contracts Country Dental Care Dental Cavity Lining Dental Cements Dental Materials Dental Pulp Dental Pulp Capping Dentists Durapatite Endodontics Ensure Environment Evaluation Experimental Designs Extravasation Government Gutta-Percha Healed Hour Hydroxyapatites Implant In Situ In Vitro Infection Minerals Mus Natural regeneration Operative Surgical Procedures Outcome Patients Periodontal Ligament Persons Phase Phosphate Buffer Plant Roots Powder dose form Precipitation Predisposition Probability Procedures Property Prosthesis Pulp Canals Pulpotomy Quickset Research Resistance Root Canal Obturation Root Canal Therapy Root Resorption Saline Silicates Solubility Solutions Surface System Testing Time Tissues Tooth structure Work Workplace antimicrobial base biomaterial compatibility blastomere structure canals sealer cost cytotoxic cytotoxicity test healing improved in vivo injured meetings oral infection public health relevance repaired response seal standard of care success tissue regeneration

项目摘要

DESCRIPTION (provided by applicant): Quick-Set Endodontic Material Additions are shown in this new font. This project is to develop a dental material that sets in about 15 minutes, and is suitable for use in surgical or non-surgical endodontic procedures. The material is intended to be an improvement on the present standard of care, ProRoot MTA material which suffers from clinical deficiencies of long setting times (hours), difficulty in placement and retention, lower than desired radiopacity, and inability to set under acid conditions. Clinicians have also been unaccepting of the high cost for ProRoot MTA, which is about $50 per gram, or about $10 to $20 per treatment. Besides being quick-setting and washout resistant, the new material will be a material that contains calcium, has a high pH, and will contain hydroxylapatite. The new material will be developed to exceed ProRoot MTA's radiopacity, ability to set in high pH environments found in some oral infections. The new material must be as bioactive as MTA, having a high pH and containing hydroxylapatite. Such a quick-setting material will make the clinical procedures shorter and more consistent, which will be of benefit to the patient and clinician, and enhance the probability for a positive outcome. The new material should promote regeneration of the periodontal ligament and cemental tissues that are injured by endodontic infections or removed during endodontic procedures. Such regeneration of tissues enhances the biological seal of the root canal system to reduce the possibility of re-infection, and enhance tooth retention. The research will use experimental designs to ensure the new material meets the ISO 6876 and ISO 9917 standards for root canal sealers and dental cements for radiopacity, setting & working times, solubility, dimensional stability, and strength. Washout testing should determine the stability for clinical use. Micro leakage testing will test the new material's suitability for endodontic use where low micro leakage is crucial. In vitro bioactivity will be tested by soaking prepared teeth in phosphate buffered saline solutions to observe the in situ precipitation of hydroxylapatite. The clinical handling and filling of roots and dentinal tubules will also be tested. Cytotoxicity tests with mouse embryonic cells will screen the biocompatibility test of the new material.) PUBLIC HEALTH RELEVANCE: Quick-Set Endodontic Material Deletions in this revised document are indicated by strikethrough and additions are shown in this new font. A new endodontic material is to be developed to enable dentists performing root canal therapy to complete the procedures more quickly, with a material is superior to the present standard of care (ProRoot MTA material). The new material will: be quicker-setting (minutes not hours), be much more resistant to washout, set when an infection is present, be more opaque to x-rays, be anti- microbial, and be as bioactive as the standard of care material. All these qualities would enhance the procedures for the clinician and the patient, and improve the outcome for tooth retention after root canal treatment, or dental pulp healing. Tooth retention eliminates the need for other procedures such as extraction, implants, and prosthetic devices. Such a new material would be a new combination of features and an advantage for dental care when treating infected teeth, especially to be confident that the material will set and remain in situ.

描述（由申请人提供）：Quick-Set牙髓材料添加以这种新字体显示。该项目旨在开发一种牙科材料，可在约15分钟内固化，适用于外科或非外科牙髓手术。该材料旨在对现有标准护理ProRoot MTA材料进行改进，ProRoot MTA材料存在凝固时间长（小时）、难以放置和保留、低于预期的射线不透性以及在酸性条件下无法凝固的临床缺陷。临床医生也一直不接受ProRoot MTA的高成本，每克约50美元，或每次治疗约10至20美元。除了快速凝固和耐冲刷外，新材料将是一种含有钙的材料，具有高pH值，并含有羟基磷灰石。新材料的开发将超过ProRoot MTA的不透射线性，能够在一些口腔感染中发现的高pH环境中设置。这种新材料必须像MTA一样具有生物活性，具有高pH值并含有羟基磷灰石。这种快速固化材料将使临床程序更短且更一致，这将有益于患者和临床医生，并提高积极结果的可能性。新材料应促进牙周韧带和牙骨质组织的再生，这些组织因根管感染而受损或在根管治疗过程中被移除。组织的这种再生增强了根管系统的生物密封，以减少再感染的可能性，并增强牙齿固位。该研究将使用实验设计，以确保新材料符合ISO 6876和ISO 9917标准的根管封闭剂和牙科水泥的不透射线性，凝固和工作时间，溶解度，尺寸稳定性和强度。洗脱试验应确定临床使用的稳定性。微渗漏测试将测试新材料在低微渗漏至关重要的牙髓应用中的适用性。将制备好的牙齿浸泡在磷酸盐缓冲盐水溶液中，观察羟基磷灰石的原位沉淀，以测试体外生物活性。还将测试牙根和牙本质小管的临床处理和填充。小鼠胚胎细胞的细胞毒性试验将筛选新材料的生物相容性试验。）公共卫生关系：在此修订文件中，Quick-Set牙髓材料删除部分用删除线表示，添加部分用新字体表示。将开发一种新的根管材料，使牙科医生能够更快地完成根管治疗，该材料上级于目前的护理标准（ProRoot MTA材料）。新材料将：更快凝固（几分钟而不是几小时）、更耐冲洗、在感染存在时凝固、对X射线更不透明、抗微生物、以及与护理材料的标准一样具有生物活性。所有这些品质都将增强临床医生和患者的程序，并改善根管治疗后牙齿保留或牙髓愈合的结果。牙齿保留消除了对其他程序的需要，如提取，植入物和修复装置。这种新材料将是一种新的特征组合，并且在治疗受感染的牙齿时对牙齿护理具有优势，特别是可以确信材料将固定并保持在原位。